Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma

• Published in: Journal of allergy and clinical immunology Vol. 99; no. 5; pp. 657 - 665
• Main Authors: Humbert, Marc, Durham, Stephen R., Kimmitt, Patrick, Powell, Nicholas, Assoufi, Basil, Pfister, Rudi, Menz, Günter, Kay, A.Barry, Corrigan, Chris J.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.05.1997; Elsevier
• Subjects: Adult; Allergic diseases; Asthma; Asthma - complications; Asthma - metabolism; atopy; Biological and medical sciences; Biopsy; Bronchi - metabolism; Bronchoscopy; eosinophil; Eosinophils - cytology; Female; Humans; Hypersensitivity, Immediate - complications; Hypersensitivity, Immediate - metabolism; IL-13; Immunoglobulin E - blood; Immunohistochemistry; Immunopathology; Interleukin-13 - biosynthesis; Leukocyte Count; Male; Medical sciences; Middle Aged; Mucous Membrane - metabolism; pathogenesis; Polymerase Chain Reaction; Respiratory and ent allergic diseases; RNA, Messenger - biosynthesis; pathogenesis; VCAM-1; RT-PCR; atopy; cDNA; mRNA; IL-13; eosinophil; Asthma; Human; Allergy; Immunopathology; Messenger RNA; Respiratory disease; Pathogenesis; Cytokine; Interleukin 13; Obstructive pulmonary disease; Gene expression; Atopy

Local secretion of cytokines by T cells within the bronchial mucosa, with consequent selective eosinophil influx, has been implicated in the pathogenesis of bronchial asthma. The cytokine IL-13 exhibits activities (selective eosinophil vascular adhesion by very late antigen-4/vascular cell adhesion...