A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives
Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, and berry fruits. It is renowned for its several health advantages. The phytochemical is well known for its anticancer properties, and a substantial amount of clinical evi...
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| Published in | Phytotherapy research Vol. 38; no. 8; pp. 3877 - 3898 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.08.2024
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, and berry fruits. It is renowned for its several health advantages. The phytochemical is well known for its anticancer properties, and a substantial amount of clinical evidence has also established its promise as a chemotherapeutic agent. This study focuses on assessing the anticancer properties of resveratrol and gaining insight into the underlying molecular mechanisms. It also evaluates the biopharmaceutical, toxicological characteristics, and clinical utilization of resveratrol to determine its suitability for further development as a reliable anticancer agent. Therefore, the information about preclinical and clinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings from this study revealed that resveratrol has potent therapeutic benefits against various cancers involving different molecular mechanisms, such as induction of oxidative stress, cytotoxicity, inhibition of cell migration and invasion, autophagy, arresting of the S phase of the cell cycle, apoptotic, anti‐angiogenic, and antiproliferative effects by regulating different molecular pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, and so on. However, the compound has poor oral bioavailability due to reduced absorption; this limitation is overcome by applying nanotechnology (nanoformulation of resveratrol). Clinical application also showed therapeutic benefits in several types of cancer with no serious adverse effects. We suggest additional extensive studies to further check the efficacy, safety, and long‐term hazards. This could involve a larger number of clinical samples to establish the compound as a reliable drug in the treatment of cancer.
Therapeutic potential of resveratrol on cancer and molecular mechanims based on different preclinical and clinical assessments. |
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| AbstractList | Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, and berry fruits. It is renowned for its several health advantages. The phytochemical is well known for its anticancer properties, and a substantial amount of clinical evidence has also established its promise as a chemotherapeutic agent. This study focuses on assessing the anticancer properties of resveratrol and gaining insight into the underlying molecular mechanisms. It also evaluates the biopharmaceutical, toxicological characteristics, and clinical utilization of resveratrol to determine its suitability for further development as a reliable anticancer agent. Therefore, the information about preclinical and clinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings from this study revealed that resveratrol has potent therapeutic benefits against various cancers involving different molecular mechanisms, such as induction of oxidative stress, cytotoxicity, inhibition of cell migration and invasion, autophagy, arresting of the S phase of the cell cycle, apoptotic, anti‐angiogenic, and antiproliferative effects by regulating different molecular pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, and so on. However, the compound has poor oral bioavailability due to reduced absorption; this limitation is overcome by applying nanotechnology (nanoformulation of resveratrol). Clinical application also showed therapeutic benefits in several types of cancer with no serious adverse effects. We suggest additional extensive studies to further check the efficacy, safety, and long‐term hazards. This could involve a larger number of clinical samples to establish the compound as a reliable drug in the treatment of cancer.
Therapeutic potential of resveratrol on cancer and molecular mechanims based on different preclinical and clinical assessments. Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, and berry fruits. It is renowned for its several health advantages. The phytochemical is well known for its anticancer properties, and a substantial amount of clinical evidence has also established its promise as a chemotherapeutic agent. This study focuses on assessing the anticancer properties of resveratrol and gaining insight into the underlying molecular mechanisms. It also evaluates the biopharmaceutical, toxicological characteristics, and clinical utilization of resveratrol to determine its suitability for further development as a reliable anticancer agent. Therefore, the information about preclinical and clinical studies was collected from different electronic databases up-to-date (2018-2023). Findings from this study revealed that resveratrol has potent therapeutic benefits against various cancers involving different molecular mechanisms, such as induction of oxidative stress, cytotoxicity, inhibition of cell migration and invasion, autophagy, arresting of the S phase of the cell cycle, apoptotic, anti-angiogenic, and antiproliferative effects by regulating different molecular pathways including PI3K/AKT, p38/MAPK/ERK, NGFR-AMPK-mTOR, and so on. However, the compound has poor oral bioavailability due to reduced absorption; this limitation is overcome by applying nanotechnology (nanoformulation of resveratrol). Clinical application also showed therapeutic benefits in several types of cancer with no serious adverse effects. We suggest additional extensive studies to further check the efficacy, safety, and long-term hazards. This could involve a larger number of clinical samples to establish the compound as a reliable drug in the treatment of cancer. Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, and berry fruits. It is renowned for its several health advantages. The phytochemical is well known for its anticancer properties, and a substantial amount of clinical evidence has also established its promise as a chemotherapeutic agent. This study focuses on assessing the anticancer properties of resveratrol and gaining insight into the underlying molecular mechanisms. It also evaluates the biopharmaceutical, toxicological characteristics, and clinical utilization of resveratrol to determine its suitability for further development as a reliable anticancer agent. Therefore, the information about preclinical and clinical studies was collected from different electronic databases up-to-date (2018-2023). Findings from this study revealed that resveratrol has potent therapeutic benefits against various cancers involving different molecular mechanisms, such as induction of oxidative stress, cytotoxicity, inhibition of cell migration and invasion, autophagy, arresting of the S phase of the cell cycle, apoptotic, anti-angiogenic, and antiproliferative effects by regulating different molecular pathways including PI3K/AKT, p38/MAPK/ERK, NGFR-AMPK-mTOR, and so on. However, the compound has poor oral bioavailability due to reduced absorption; this limitation is overcome by applying nanotechnology (nanoformulation of resveratrol). Clinical application also showed therapeutic benefits in several types of cancer with no serious adverse effects. We suggest additional extensive studies to further check the efficacy, safety, and long-term hazards. This could involve a larger number of clinical samples to establish the compound as a reliable drug in the treatment of cancer.Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, and berry fruits. It is renowned for its several health advantages. The phytochemical is well known for its anticancer properties, and a substantial amount of clinical evidence has also established its promise as a chemotherapeutic agent. This study focuses on assessing the anticancer properties of resveratrol and gaining insight into the underlying molecular mechanisms. It also evaluates the biopharmaceutical, toxicological characteristics, and clinical utilization of resveratrol to determine its suitability for further development as a reliable anticancer agent. Therefore, the information about preclinical and clinical studies was collected from different electronic databases up-to-date (2018-2023). Findings from this study revealed that resveratrol has potent therapeutic benefits against various cancers involving different molecular mechanisms, such as induction of oxidative stress, cytotoxicity, inhibition of cell migration and invasion, autophagy, arresting of the S phase of the cell cycle, apoptotic, anti-angiogenic, and antiproliferative effects by regulating different molecular pathways including PI3K/AKT, p38/MAPK/ERK, NGFR-AMPK-mTOR, and so on. However, the compound has poor oral bioavailability due to reduced absorption; this limitation is overcome by applying nanotechnology (nanoformulation of resveratrol). Clinical application also showed therapeutic benefits in several types of cancer with no serious adverse effects. We suggest additional extensive studies to further check the efficacy, safety, and long-term hazards. This could involve a larger number of clinical samples to establish the compound as a reliable drug in the treatment of cancer. |
| Author | Ali, Md. Arman Mubarak, Mohammad S. Afroz, Meher Akter, Mst. Asma Akbor, Md. Showkot Islam, Muhammad Torequl Sonia, Fatema Akter Bhuia, Md. Shimul Chowdhury, Raihan |
| Author_xml | – sequence: 1 givenname: Md. Shimul orcidid: 0000-0002-6179-9720 surname: Bhuia fullname: Bhuia, Md. Shimul organization: BioLuster Research Center – sequence: 2 givenname: Raihan orcidid: 0009-0007-0672-6581 surname: Chowdhury fullname: Chowdhury, Raihan organization: BioLuster Research Center – sequence: 3 givenname: Mst. Asma orcidid: 0009-0004-5010-7030 surname: Akter fullname: Akter, Mst. Asma organization: Bangabandhu Sheikh Mujibur Rahman Science and Technology University – sequence: 4 givenname: Md. Arman orcidid: 0009-0005-6646-3619 surname: Ali fullname: Ali, Md. Arman organization: Bangabandhu Sheikh Mujibur Rahman Science and Technology University – sequence: 5 givenname: Meher orcidid: 0009-0008-7383-802X surname: Afroz fullname: Afroz, Meher organization: Bangabandhu Sheikh Mujibur Rahman Science and Technology University – sequence: 6 givenname: Md. Showkot orcidid: 0000-0001-5420-9924 surname: Akbor fullname: Akbor, Md. Showkot organization: Bangabandhu Sheikh Mujibur Rahman Science and Technology University – sequence: 7 givenname: Fatema Akter surname: Sonia fullname: Sonia, Fatema Akter organization: Bangabandhu Sheikh Mujibur Rahman Science and Technology University – sequence: 8 givenname: Mohammad S. orcidid: 0000-0002-9782-0835 surname: Mubarak fullname: Mubarak, Mohammad S. email: mmubarak@ju.edu.jo organization: The University of Jordan – sequence: 9 givenname: Muhammad Torequl orcidid: 0000-0001-6392-3820 surname: Islam fullname: Islam, Muhammad Torequl email: dmt.islam@bsmrstu.edu.bd organization: Khulna University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38768953$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1080_17568919_2024_2435251 crossref_primary_10_1002_slct_202404764 crossref_primary_10_1039_D4NJ04125A crossref_primary_10_1016_j_phymed_2024_156127 crossref_primary_10_3390_ijms252413338 crossref_primary_10_1016_j_crfs_2025_100972 crossref_primary_10_1016_j_fbio_2025_106368 crossref_primary_10_1016_j_fochx_2025_102182 crossref_primary_10_1155_2024_5594462 |
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| Snippet | Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, and berry fruits. It is... |
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| SubjectTerms | 1-Phosphatidylinositol 3-kinase absorption AKT protein Angiogenesis Animals Anticancer properties antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic drugs Apoptosis Apoptosis - drug effects Autophagy Bioavailability biopharmaceuticals Cancer Cell cycle Cell migration cell movement Chemotherapy Cytotoxicity drug therapy Fruits Humans Information processing interphase MAP kinase Molecular modelling Nanotechnology Neoplasms - drug therapy Nerve growth factor receptors Oxidative stress pharmacokinetics Pharmacology Phytochemicals phytotherapy Resveratrol Resveratrol - pharmacology S phase TOR protein |
| Title | A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fptr.8239 https://www.ncbi.nlm.nih.gov/pubmed/38768953 https://www.proquest.com/docview/3092294544 https://www.proquest.com/docview/3057692070 https://www.proquest.com/docview/3153713493 |
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