Clinical Photodynamic Diagnosis and Therapy Efficiency in Oropharyngeal Cancer

Objectives; We studied photodynamic diagnosis (PDD) and therapy (PDT) applicability using NPe6 in with oropharyngeal cancer patients. Methods; Of 11 subjects diagnosed with oropharyngeal cancer undergoing PDT and PDD using NPe6, 6 were stage T1 and 5 stage T2. None had nodal or distant metastases. F...

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Published inNippon Jibi Inkoka Gakkai Kaiho Vol. 112; no. 5; pp. 429 - 433
Main Authors Yoshida, Tomoyuki, Okamoto, Isaku, Konomi, Ujimoto, Shimizu, Shigetaka, Shimizu, Akira, Ito, Hiroyuki, Suzuki, Mamoru
Format Journal Article
LanguageJapanese
Published Japan The Oto-Rhino-Laryngological Society of Japan, Inc 2009
Subjects
Adult
Aged
Aged, 80 and over
Female
Humans
laser treatment oropharyngeal cancer
Male
Middle Aged
NPe6
Oropharyngeal Neoplasms - diagnosis
Oropharyngeal Neoplasms - drug therapy
Photochemotherapy - methods
photodynamic diagnosis
photodynamic therapy
Photosensitizing Agents - therapeutic use
Porphyrins - therapeutic use
Online AccessGet full text
ISSN0030-6622
1883-0854
DOI10.3950/jibiinkoka.112.429

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Abstract Objectives; We studied photodynamic diagnosis (PDD) and therapy (PDT) applicability using NPe6 in with oropharyngeal cancer patients. Methods; Of 11 subjects diagnosed with oropharyngeal cancer undergoing PDT and PDD using NPe6, 6 were stage T1 and 5 stage T2. None had nodal or distant metastases. Four hours before PDD, NPe6 (40 mg/m2) was injected intravenously. Under general anesthesia, tumor fluorescence observed by laser irradiation, and marked was followed by PDT and photobleaching was confirmed. Tissue collected from tumor centers confirming NPe6 was then compared to normal tissue specimens and the relationship between NPe6 concentration and treatment effectiveness studied. Results; Tumor marking enabled us ensure a safety margin because the fluorescence scope exceeded tumor scope to the naked eye. Photobleaching was confirmed in all subjects. NPe6 tumor tissue concentration was 1.57-6.84 μg/g, with a ratio of 2.32-5.69 compared to normal tissue. Treatment achieved complete recovery (CR) in all subjects and shortened hospitalization over other treatment such as radiation. Conclusion; PDD using NPe6 clearly benefited oropharyngeal cancer patients, and made PDT more accurate. NPe6 accumulated more than twice the level in tumor tissue than in normal tissue.
AbstractList OBJECTIVESWe studied photodynamic diagnosis (PDD) and therapy (PDT) applicability using NPe6 in with oropharyngeal cancer patients.METHODSOf 11 subjects diagnosed with oropharyngeal cancer undergoing PDT and PDD using NPe6, 6 were stage T1 and 5 stage T2. None had nodal or distant metastases. Four hours before PDD, NPe6 (40 mg/mD) was injected intravenously. Under general anesthesia, tumor fluorescence observed by laser irradiation, and marked was followed by PDT and photobleaching was confirmed. Tissue collected from tumor centers confirming NPe6 was then compared to normal tissue specimens and the relationship between NPe6 concentration and treatment effectiveness studied.RESULTSTumor marking enabled us ensure a safety margin because the fluorescence scope exceeded tumor scope to the naked eye. Photobleaching was confirmed in all subjects. NPe6 tumor tissue concentration was 1.57-6.84 microg/g, with a ratio of 2.32-5.69 compared to normal tissue. Treatment achieved complete recovery (CR) in all subjects and shortened hospitalization over other treatment such as radiation.CONCLUSIONPDD using NPe6 clearly benefited oropharyngeal cancer patients, and made PDT more accurate. NPe6 accumulated more than twice the level in tumor tissue than in normal tissue.
Objectives; We studied photodynamic diagnosis (PDD) and therapy (PDT) applicability using NPe6 in with oropharyngeal cancer patients. Methods; Of 11 subjects diagnosed with oropharyngeal cancer undergoing PDT and PDD using NPe6, 6 were stage T1 and 5 stage T2. None had nodal or distant metastases. Four hours before PDD, NPe6 (40 mg/m2) was injected intravenously. Under general anesthesia, tumor fluorescence observed by laser irradiation, and marked was followed by PDT and photobleaching was confirmed. Tissue collected from tumor centers confirming NPe6 was then compared to normal tissue specimens and the relationship between NPe6 concentration and treatment effectiveness studied. Results; Tumor marking enabled us ensure a safety margin because the fluorescence scope exceeded tumor scope to the naked eye. Photobleaching was confirmed in all subjects. NPe6 tumor tissue concentration was 1.57-6.84 μg/g, with a ratio of 2.32-5.69 compared to normal tissue. Treatment achieved complete recovery (CR) in all subjects and shortened hospitalization over other treatment such as radiation. Conclusion; PDD using NPe6 clearly benefited oropharyngeal cancer patients, and made PDT more accurate. NPe6 accumulated more than twice the level in tumor tissue than in normal tissue.
We studied photodynamic diagnosis (PDD) and therapy (PDT) applicability using NPe6 in with oropharyngeal cancer patients. Of 11 subjects diagnosed with oropharyngeal cancer undergoing PDT and PDD using NPe6, 6 were stage T1 and 5 stage T2. None had nodal or distant metastases. Four hours before PDD, NPe6 (40 mg/mD) was injected intravenously. Under general anesthesia, tumor fluorescence observed by laser irradiation, and marked was followed by PDT and photobleaching was confirmed. Tissue collected from tumor centers confirming NPe6 was then compared to normal tissue specimens and the relationship between NPe6 concentration and treatment effectiveness studied. Tumor marking enabled us ensure a safety margin because the fluorescence scope exceeded tumor scope to the naked eye. Photobleaching was confirmed in all subjects. NPe6 tumor tissue concentration was 1.57-6.84 microg/g, with a ratio of 2.32-5.69 compared to normal tissue. Treatment achieved complete recovery (CR) in all subjects and shortened hospitalization over other treatment such as radiation. PDD using NPe6 clearly benefited oropharyngeal cancer patients, and made PDT more accurate. NPe6 accumulated more than twice the level in tumor tissue than in normal tissue.
Author Konomi, Ujimoto
Shimizu, Shigetaka
Ito, Hiroyuki
Okamoto, Isaku
Shimizu, Akira
Yoshida, Tomoyuki
Suzuki, Mamoru
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CitedBy_id crossref_primary_10_5631_jibirin_102_889
crossref_primary_10_1016_j_pdpdt_2017_11_016
crossref_primary_10_1002_lsm_21048
crossref_primary_10_5005_jp_journals_10003_1036
Cites_doi 10.1007/s10103-007-0469-3
10.1155/DTE.3.41
10.1001/archotol.129.1.36
10.1002/(SICI)1096-9101(1996)19:2<168::AID-LSM7>3.3.CO;2-1
10.1001/archderm.1960.01580040026005
10.3171/jns.2000.93.6.1003
10.1016/0016-5085(95)90058-6
10.1155/DTE.5.183
10.1016/S0169-5002(03)00242-3
10.1288/00005537-197103000-00003
10.1007/s00405-003-0694-8
10.3950/jibiinkoka.98.795
10.1093/jnci/80.5.330
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References 13) 吉田知之, 加藤治文, 佐伯哲郎, 奥平唯雄, 李雅次, 他: 頭頸部癌に対する光線力学的療法の臨床応用. 頭頸部外科 1996; 6: 111-117.
18) Stummer W, Novotny A, Stepp H, Goetz C, Bise K, et al: Fluorescence-Guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients. J Neurosurg 2000; 93: 1003-1013.
17) Roberts WG, Shiau FY, Nelson JS, Smith KM, Berns MW: In vitro characterization of monoaspartryl chlorin e6 and diaspartyl chlorine e6 for photodynamic therapy. J Natl Cancer Inst 1988; 80: 330-336.
9) Muroya T, Kawasaki K, Suehiro Y, Kunugi T, Umayahara K, et al: Application of PDT for Uterine Cervical Cancer. Diagn Ther Endosc 1999; 5: 183-190.
15) Steiner W, Fierek O, Ambrosch P, Hommerich CP, Kron M: Transoral Laser Microsurgery for Squamous Cell Carcinoma of the Base of the Tongue. Otolaryngol Head Neck Surg 2003; 129: 36-43.
8) Mimura S, Ito Y, Nagayo T, Ichii M, Kato H, et al: Cooper-ative clinical trial of photodynamic therapy with Photofrin IIand excimer dye laser for early gastric cancer. Lasers Surg Med 1996; 19: 168-172.
10) Leonard JR, Beck WL; Hematoporphyrin fluorescence: an aid in diagnosis of malignant neoplasms. Laryngoscope 1971; 81: 365-372.
21) Kato H, Furukawa K, Sato M, Okunaka T, kusunoki Y, et al : Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorine e6 and diode laser for early squamous cell carcinoma of the lung. Lung cancer 2003; 42: 103-111.
11) 吉田知之, 加藤治文, 佐伯哲郎, 大橋伸也: 喉頭癌に対する光線力学的療法の臨床的検討. 日耳鼻 1995; 98: 795-804.
14) Alain C, Jean-Pierre R, Olivier D, Stephane T, Francois M, et al: T1-T2 N0 oropharyngeal cancers treated with surgery alone. Eur Arch Otorhinolaryngol 2004; 261: 276-281.
4) 會沢勝夫, 黒岩ゆかり, 土田敬明, Ilyar Xiahedin, 渋谷洋, 他: 光感受性物質の細胞内動態. 癌と化学療法 1996; 23: 22-26.
5) Lipson RL, Baldes EJ: The photodynamic propertiesof a particular hematoporphyrin derivative. Arch Dermatol 1960; 82: 508-516.
7) Sibille A, Lambert R, Souquet JC, Sabben G, Descos F: Long-term survival after photodynamic therapy for esophageal cancer. Gastroenterology 1995; 108: 337-344.
16) 中島進, 竹村健, 阪田功: PDTの原理と光感受性物質の動向. PDTハンドブック. 加藤治文監, 奥伸哲弥編, 医学書院; 2002: 1-10頁.
1) 臼田実男, 加藤治文: 総説癌治療における光線力学的治療の現状. Biotherapy 2005; 19: 311-316.
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1
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9
YOSHIDA TOMOYUKI (11) 1995; 98
20
10
21
References_xml – reference: 5) Lipson RL, Baldes EJ: The photodynamic propertiesof a particular hematoporphyrin derivative. Arch Dermatol 1960; 82: 508-516.
– reference: 7) Sibille A, Lambert R, Souquet JC, Sabben G, Descos F: Long-term survival after photodynamic therapy for esophageal cancer. Gastroenterology 1995; 108: 337-344.
– reference: 4) 會沢勝夫, 黒岩ゆかり, 土田敬明, Ilyar Xiahedin, 渋谷洋, 他: 光感受性物質の細胞内動態. 癌と化学療法 1996; 23: 22-26.
– reference: 17) Roberts WG, Shiau FY, Nelson JS, Smith KM, Berns MW: In vitro characterization of monoaspartryl chlorin e6 and diaspartyl chlorine e6 for photodynamic therapy. J Natl Cancer Inst 1988; 80: 330-336.
– reference: 12) Yoshida T, Kato H, Okunaka T, Saeki T, Ohashi S, et al: Photodynamic therapy for head and neck cancer. DTE 1996; 3: 41-51.
– reference: 21) Kato H, Furukawa K, Sato M, Okunaka T, kusunoki Y, et al : Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorine e6 and diode laser for early squamous cell carcinoma of the lung. Lung cancer 2003; 42: 103-111.
– reference: 3) 吉田知之: 治療光線力学的治療. JOHNS 2001; 17: 89-93.
– reference: 6) Dougherty TJ, Kaufman JE, Goldfarb A, Weishaupt KR, Boyle D, et al: Photoradiation therapy for the treatment of malignant tumors. Cancer Res 1978; 38: 2628-2635.
– reference: 20) 大崎能伸, 澁川紀代子: Photodynamic Diagnosisの診断への応用. The Journal of the Japan Society for Respiratory Endoscopy 2006; 28: 482-486.
– reference: 1) 臼田実男, 加藤治文: 総説癌治療における光線力学的治療の現状. Biotherapy 2005; 19: 311-316.
– reference: 10) Leonard JR, Beck WL; Hematoporphyrin fluorescence: an aid in diagnosis of malignant neoplasms. Laryngoscope 1971; 81: 365-372.
– reference: 13) 吉田知之, 加藤治文, 佐伯哲郎, 奥平唯雄, 李雅次, 他: 頭頸部癌に対する光線力学的療法の臨床応用. 頭頸部外科 1996; 6: 111-117.
– reference: 14) Alain C, Jean-Pierre R, Olivier D, Stephane T, Francois M, et al: T1-T2 N0 oropharyngeal cancers treated with surgery alone. Eur Arch Otorhinolaryngol 2004; 261: 276-281.
– reference: 15) Steiner W, Fierek O, Ambrosch P, Hommerich CP, Kron M: Transoral Laser Microsurgery for Squamous Cell Carcinoma of the Base of the Tongue. Otolaryngol Head Neck Surg 2003; 129: 36-43.
– reference: 18) Stummer W, Novotny A, Stepp H, Goetz C, Bise K, et al: Fluorescence-Guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients. J Neurosurg 2000; 93: 1003-1013.
– reference: 19) Matsumura H, Akimoto J, Haraoka J, Aizawa K: Uptake and retention of the photosensitizer mono-L-asparthyl chlorine e6 in experimental malignant glioma. Lasers in Med Sci 2007; 23 : 237-245.
– reference: 8) Mimura S, Ito Y, Nagayo T, Ichii M, Kato H, et al: Cooper-ative clinical trial of photodynamic therapy with Photofrin IIand excimer dye laser for early gastric cancer. Lasers Surg Med 1996; 19: 168-172.
– reference: 11) 吉田知之, 加藤治文, 佐伯哲郎, 大橋伸也: 喉頭癌に対する光線力学的療法の臨床的検討. 日耳鼻 1995; 98: 795-804.
– reference: 16) 中島進, 竹村健, 阪田功: PDTの原理と光感受性物質の動向. PDTハンドブック. 加藤治文監, 奥伸哲弥編, 医学書院; 2002: 1-10頁.
– reference: 2) 吉田知之, 清水顕, 中村一博, 清水重敬, 竹之内剛, 他: 新規光感受性薬剤とダイオードレーザーを使用した光線力学的療法の早期喉頭癌への応用. 日気食 2007; 58: 17-24.
– reference: 9) Muroya T, Kawasaki K, Suehiro Y, Kunugi T, Umayahara K, et al: Application of PDT for Uterine Cervical Cancer. Diagn Ther Endosc 1999; 5: 183-190.
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  doi: 10.1001/archotol.129.1.36
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  doi: 10.1002/(SICI)1096-9101(1996)19:2<168::AID-LSM7>3.3.CO;2-1
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  doi: 10.1001/archderm.1960.01580040026005
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  doi: 10.3171/jns.2000.93.6.1003
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  doi: 10.1016/0016-5085(95)90058-6
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  doi: 10.1155/DTE.5.183
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  doi: 10.1016/S0169-5002(03)00242-3
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Snippet Objectives; We studied photodynamic diagnosis (PDD) and therapy (PDT) applicability using NPe6 in with oropharyngeal cancer patients. Methods; Of 11 subjects...
We studied photodynamic diagnosis (PDD) and therapy (PDT) applicability using NPe6 in with oropharyngeal cancer patients. Of 11 subjects diagnosed with...
OBJECTIVESWe studied photodynamic diagnosis (PDD) and therapy (PDT) applicability using NPe6 in with oropharyngeal cancer patients.METHODSOf 11 subjects...
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SubjectTerms Adult
Aged
Aged, 80 and over
Female
Humans
laser treatment oropharyngeal cancer
Male
Middle Aged
NPe6
Oropharyngeal Neoplasms - diagnosis
Oropharyngeal Neoplasms - drug therapy
Photochemotherapy - methods
photodynamic diagnosis
photodynamic therapy
Photosensitizing Agents - therapeutic use
Porphyrins - therapeutic use
Title Clinical Photodynamic Diagnosis and Therapy Efficiency in Oropharyngeal Cancer
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ispartofPNX Nippon Jibiinkoka Gakkai Kaiho, 2009, Vol.112(5), pp.429-433
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