Static and Dynamic Stereochemistry of Chiral Ln DOTA Analogues

• Published in: Chemphyschem Vol. 12; no. 8; pp. 1490 - 1497
• Main Authors: Di Bari, Lorenzo, Salvadori, Piero
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 06.06.2011; WILEY‐VCH Verlag
• Subjects: chirality; circular dichroism; conformation; lanthanides; MRI contrast agents

Ln DOTA derivatives (DOTA=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid) are known to undergo relevant stereoisomeric equilibria in solution, which greatly modulate their chemical as well as their magnetic and optical properties. The subject is reviewed in terms of classical stereochemica...