Hepatitis Flare During Immunotherapy in Patients With Current or Past Hepatitis B Virus Infection

• Published in: The American journal of gastroenterology Vol. 116; no. 6; pp. 1274 - 1283
• Main Authors: Wong, Grace Lai-Hung, Wong, Vincent Wai-Sun, Hui, Vicki Wing-Ki, Yip, Terry Cheuk-Fung, Tse, Yee-Kit, Liang, Lilian Yan, Lui, Rashid Nok-Shun, Mok, Tony Shu-Kam, Chan, Henry Lik-Yuen, Chan, Stephen Lam
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.06.2021; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Administration, Oral; Aged; Alanine Transaminase - blood; Antibodies; Antigens; Antiviral Agents - administration & dosage; Antiviral drugs; Biomarkers - blood; Drug dosages; Female; Gastroenterology; Hepatitis B; Hepatitis B - drug therapy; Hepatitis B - immunology; Hepatitis B Surface Antigens - immunology; Hepatitis C; Hong Kong; Humans; Immune Checkpoint Inhibitors - adverse effects; Immunotherapy; Infections; Interferon; Laboratories; Liver; Liver Function Tests; Male; Middle Aged; Patients; Retrospective Studies; Risk Factors; Symptom Flare Up; Virus Activation - drug effects; Virus Activation - immunology; Hong Kong; Hong Kong China; China

Immunotherapy has dramatically improved the survival of patients with advanced or metastatic malignancies. Recent studies suggest that immunotherapy may increase the risk of hepatitis, whereas it may also induce functional cure of chronic hepatitis B virus (HBV) infection. We evaluated the incidence...