In vitro antiviral efficacy of amenamevir against feline herpesvirus 1

• Published in: Journal of veterinary medical science Vol. 87; no. 8; pp. 906 - 910
• Main Authors: KIKUIRI, Aoi, NISHIGAKI, Haruka, FUJII, Hikaru, WATANABE, Shumpei, KOJIMA, Isshu, MORIKAWA, Shigeru
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Veterinary Science 2025
• Subjects: Acyclovir - analogs & derivatives; Acyclovir - pharmacology; Animals; Antiviral Agents - pharmacology; Cats; Cell Line; Guanine; Herpesviridae Infections - drug therapy; Herpesviridae Infections - veterinary; Oxadiazoles - pharmacology; Varicellovirus - drug effects; Virology; antiviral agent; amenamevir; feline herpesvirus type 1; helicase-primase inhibitor

Amenamevir (AMNV), a helicase-primase inhibitor, has recently received approval for treating human herpesvirus infections. Herein, we evaluated the efficacy of AMNV against feline herpesvirus 1 (FHV-1) in three different cell lines and compared it with that of acyclovir (ACV) and penciclovir (PCV)-n...