Berberine ameliorates depression‐like behavior in CUMS mice by activating TPH1 and inhibiting IDO1‐associated with tryptophan metabolism

• Published in: Phytotherapy research Vol. 37; no. 1; pp. 342 - 357
• Main Authors: Ge, Ping‐Yuan, Qu, Shu‐Yue, Ni, Sai‐jia, Yao, Zeng‐Ying, Qi, Yi‐Yu, Zhao, Xin, Guo, Rui, Yang, Nian‐Yun, Zhang, Qi‐Chun, Zhu, Hua‐Xu
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.01.2023; Wiley Subscription Services, Inc
• Subjects: agonists; Animals; Antibiotics; Antidepressants; Assaying; Berberine; Berberine - pharmacology; Biotransformation; blood serum; Chromatography, Liquid; depression; Depression - drug therapy; Depression - metabolism; Dioxygenase; Disease Models, Animal; enzyme-linked immunosorbent assay; Evaluation; Hydroxylase; immunohistochemistry; indoleamine 2,3-dioxygenase; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Inflammation; interleukin-10; interleukin-4; Intestinal microflora; intestinal microorganisms; kynurenine; Metabolism; Metabolomics; Mice; Microbiota; Neurons; neuroplasticity; Neurotransmitter Agents; Neurotransmitters; phytotherapy; Serotonin; Serum levels; Stress, Psychological - drug therapy; Synapses; Synaptic plasticity; Tandem Mass Spectrometry; Tryptophan; Tryptophan - metabolism; tryptophan 5-monoxygenase; Tryptophan Hydroxylase; Tumor necrosis factor; metabolomics; depression; berberine

Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota. Depressive behaviors in mice induced using chronic unpredictable mild stress (CUMS) stimulation were evaluated by behavioral experiments. The markers of neurons and synapses were measured u...