Berberine ameliorates depression‐like behavior in CUMS mice by activating TPH1 and inhibiting IDO1‐associated with tryptophan metabolism - Ge, Ping‐Yuan; Qu, Shu‐Yue; Ni, Sai‐jia; Yao, Zeng‐Ying; Qi, Yi‐Yu; Zhao, Xin; Guo, Rui; Yang, Nian‐Yun; Zhang, Qi‐Chun; Zhu, Hua‐Xu (Phytotherapy research, 2023)
Keywords: agonists; Animals; Antibiotics; Antidepressants; Assaying; Berberine; Berberine - pharmacology; Biotransformation; blood serum; Chromatography, Liquid; depression; Depression - drug therapy; Depression - metabolism; Dioxygenase; Disease Models, Animal; enzyme-linked immunosorbent assay; Evaluation; Hydroxylase; immunohistochemistry; indoleamine 2,3-dioxygenase; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Inflammation; interleukin-10; interleukin-4; Intestinal microflora; intestinal microorganisms; kynurenine; Metabolism; Metabolomics; Mice; Microbiota; Neurons; neuroplasticity; Neurotransmitter Agents; Neurotransmitters; phytotherapy; Serotonin; Serum levels; Stress, Psychological - drug therapy; Synapses; Synaptic plasticity; Tandem Mass Spectrometry; Tryptophan; Tryptophan - metabolism; tryptophan 5-monoxygenase; Tryptophan Hydroxylase; Tumor necrosis factor; metabolomics; depression; berberine