Prophylaxis against organophosphate poisoning by sustained release of scopolamine and physostigmine

• Published in: Journal of applied toxicology Vol. 21; no. S1; pp. S75 - S78
• Main Authors: Meshulam, Yacov, Cohen, Giora, Chapman, Shira, Alkalai, David, Levy, Aharon
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2001
• Subjects: Alzet; Animals; Beagle dogs; Chemical Warfare Agents - poisoning; cholinesterase; Cholinesterase Inhibitors - administration & dosage; Cholinesterase Inhibitors - pharmacokinetics; Cholinesterase Inhibitors - pharmacology; convulsions; Delayed-Action Preparations; Dogs; Dose-Response Relationship, Drug; mini-osmotic pumps; Muscarinic Antagonists - administration & dosage; Muscarinic Antagonists - pharmacokinetics; Muscarinic Antagonists - pharmacology; physostigmine; Physostigmine - administration & dosage; Physostigmine - pharmacokinetics; Physostigmine - pharmacology; Poisoning - prevention & control; sarin; Sarin - poisoning; scopolamine; Scopolamine Hydrobromide - administration & dosage; Scopolamine Hydrobromide - pharmacokinetics; Scopolamine Hydrobromide - pharmacology

Protection efficacy of continuous prophylactic administration of physostigmine and scopolamine against sarin‐induced toxicity was evaluated previously in guinea pigs. The present study in large animals used Beagle dogs, that serve as an animal model with cholinergic sensitivity similar to that of hu...