Lucidone inhibits autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt signaling pathway in pancreatic cancer cells

• Published in: Phytotherapy research Vol. 36; no. 4; pp. 1664 - 1677
• Main Authors: Chen, Sheng‐Yi, Hsu, Yi‐Hao, Wang, Sheng‐Yang, Chen, Ying‐Yin, Hong, Cheng‐Jie, Yen, Gow‐Chin
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.04.2022; Wiley Subscription Services, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; Adenocarcinoma; Advanced glycosylation end products; AKT protein; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism; Autophagy; Carcinoma, Pancreatic Ductal; Cell death; Cell Line, Tumor; Cell proliferation; Cyclopentanes; Cytotoxicity; Drug resistance; Gemcitabine; Glycosylation; HMGB1 Protein; Humans; Kinases; Lindera erythrocarpa; lucidone; MDR1; MDR1 protein; Multidrug resistance; nucleoproteins; P-Glycoprotein; P-glycoproteins; Pancreatic cancer; pancreatic ductal adenocarcinoma; Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; Phosphatidylinositol 3-Kinases - metabolism; phytotherapy; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Receptor for Advanced Glycation End Products; Signal Transduction; Signaling; siRNA; Toxicity; Transfection; Tumors; MDR1; gemcitabine; autophagy; lucidone; pancreatic ductal adenocarcinoma

Gemcitabine (GEM) drug resistance remains a difficult challenge in pancreatic ductal adenocarcinoma (PDAC) treatment. Therefore, identifying a safe and effective treatment strategy for PDAC is urgent. Lucidone is a natural compound extracted from the fruits of Lindera erythrocarpa Makino. However, t...