Lucidone inhibits autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt signaling pathway in pancreatic cancer cells - Chen, Sheng‐Yi; Hsu, Yi‐Hao; Wang, Sheng‐Yang; Chen, Ying‐Yin; Hong, Cheng‐Jie; Yen, Gow‐Chin (Phytotherapy research, 2022)
Keywords: 1-Phosphatidylinositol 3-kinase; Adenocarcinoma; Advanced glycosylation end products; AKT protein; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism; Autophagy; Carcinoma, Pancreatic Ductal; Cell death; Cell Line, Tumor; Cell proliferation; Cyclopentanes; Cytotoxicity; Drug resistance; Gemcitabine; Glycosylation; HMGB1 Protein; Humans; Kinases; Lindera erythrocarpa; lucidone; MDR1; MDR1 protein; Multidrug resistance; nucleoproteins; P-Glycoprotein; P-glycoproteins; Pancreatic cancer; pancreatic ductal adenocarcinoma; Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; Phosphatidylinositol 3-Kinases - metabolism; phytotherapy; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Receptor for Advanced Glycation End Products; Signal Transduction; Signaling; siRNA; Toxicity; Transfection; Tumors; MDR1; gemcitabine; autophagy; lucidone; pancreatic ductal adenocarcinoma