Development and validation of a prognostic model for survival time data: application to prognosis of HIV positive patients treated with antiretroviral therapy

• Published in: Statistics in medicine Vol. 23; no. 15; pp. 2375 - 2398
• Main Authors: May, Margaret, Royston, Patrick, Egger, Matthias, Justice, Amy C., Sterne, Jonathan AC
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 15.08.2004; Wiley Subscription Services, Inc
• Subjects: Anti-HIV Agents - therapeutic use; Cohort Studies; cross-validation; deviance; HIV; HIV Infections - drug therapy; Human immunodeficiency virus; Humans; Prognosis; prognostic model; Survival Analysis; survival model; validation; Validation studies

The process of developing and validating a prognostic model for survival time data has been much discussed in the literature. Assessment of the performance of candidate prognostic models on data other than that used to fit the models is essential for choosing a model that will generalize well to ind...