Proline-Based P,O Ligand/Iridium Complexes as Highly Selective Catalysts: Asymmetric Hydrogenation of Trisubstituted Alkenes

• Published in: Angewandte Chemie (International ed.) Vol. 50; no. 41; pp. 9598 - 9601
• Main Authors: Rageot, Denise, Woodmansee, David H., Pugin, Benoît, Pfaltz, Andreas
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 04.10.2011; WILEY‐VCH Verlag; Wiley
• Subjects: Alkenes - chemistry; asymmetric catalysis; asymmetric hydrogenation; Catalysis; Chemistry; Chemistry, Multidisciplinary; Hydrogenation; iridium; Iridium - chemistry; ligand design; Ligands; Molecular Structure; O ligand; P,O ligand; Physical Sciences; Proline - chemistry; Science & Technology; COORDINATION CHEMISTRY; P,O ligand; MECHANISM; CYCLOALKENONES; SUBSTITUENTS; asymmetric catalysis; IRIDIUM CATALYSTS; ARYLBORONIC ACIDS; iridium; ENANTIOSELECTIVE CONJUGATE ADDITION; CHIRAL AMIDOPHOSPHINE LIGAND; ligand design; OLEFINS; ORGANOCOPPER; asymmetric hydrogenation
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201104105

P,O joins the mix: P,O ligands (L1) form efficient iridium catalysts for the asymmetric hydrogenation of olefins. The proline‐derived ligands lead to high enantioselectivities with several classes of alkenes, most notably with α,β‐unsaturated carboxylic esters and ketones, where they match or even surpass the ee values reported for the best N,P and C,N ligands.