Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles

• Published in: Advanced materials (Weinheim) Vol. 24; no. 14; pp. 1868 - 1872
• Main Authors: Yang, Kai, Hu, Lilei, Ma, Xingxing, Ye, Shuoqi, Cheng, Liang, Shi, Xiaoze, Li, Changhui, Li, Yonggang, Liu, Zhuang
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 10.04.2012; WILEY‐VCH Verlag
• Subjects: Animals; Ferric Compounds - chemistry; graphene oxide nanocomposites; Graphite - chemistry; Magnetic Resonance Imaging; Magnetite Nanoparticles - chemistry; Magnetite Nanoparticles - therapeutic use; Mice; multimodal imaging; Nanocomposites - chemistry; Nanocomposites - therapeutic use; Neoplasms - diagnosis; Neoplasms - therapy; Oxidation-Reduction; Oxides - chemistry; photoacoustic imaging; Phototherapy; photothermal therapy; Polyethylene Glycols - chemistry
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.201104964

In this work, a nanoscale reduced graphene oxide–iron oxide nanoparticle (RGO–IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO–IONP–PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in‐vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice.