Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses - Zhang, Zufei; Imperial, Marjorie Z.; Patilea-Vrana, Gabriela I.; Wedagedera, Janak; Gaohua, Lu; Unadkat, Jashvant D. (Drug metabolism and disposition, 2017)
Keywords: Age; Computer simulation; Drug dosages; Ethics; Exposure; Female; Fetus - metabolism; Fetuses; Gestational Age; Humans; Intravenous administration; Intravenous infusion; Maternal Exposure - adverse effects; Maternal-Fetal Exchange - physiology; Mathematical models; Metabolism; Models, Biological; Oral administration; Pharmaceutical Preparations - metabolism; Pharmacokinetics; Pharmacology; Placenta; Placenta - metabolism; Pregnancy; Risk assessment; Sensitivity analysis; Steady state; Toxicity; Transport; Variation; CLPD; steady stateinf; F/M; PBPK; C-T; CLPD,u; P/M; m-f-PBPK; m-PBPK; CLMP; CLm0; ka; GA; Fa; AUCp; AUCm; Fg; UV; MP; P-gp; AUCf; CLf0; HIV; CLp0; Vss; Cmax,f; CLPM; PK