Role of Reflux in the Pathogenesis of Eosinophilic Esophagitis: Comprehensive Appraisal With Off- and On PPI Impedance-pH Monitoring

• Published in: The American journal of gastroenterology Vol. 114; no. 10; pp. 1606 - 1613
• Main Authors: Frazzoni, Marzio, Penagini, Roberto, Frazzoni, Leonardo, de Bortoli, Nicola, Mauro, Aurelio, Tolone, Salvatore, Bertani, Helga, Marsico, Maria, Marocchi, Margherita, Marchi, Santino, Conigliaro, Rita, Savarino, Edoardo
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.10.2019; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Acids; Adult; Drug Resistance; Dysphagia; Electric Impedance; Endoscopy; Eosinophilic Esophagitis - diagnosis; Eosinophilic Esophagitis - pathology; Eosinophilic Esophagitis - prevention & control; Esophageal pH Monitoring; Esophagoscopy; Esophagus; Esophagus - diagnostic imaging; Esophagus - drug effects; Esophagus - pathology; Feasibility Studies; Female; Food; Gastroesophageal reflux; Gastroesophageal Reflux - complications; Gastroesophageal Reflux - diagnosis; Gastroesophageal Reflux - drug therapy; Humans; Male; Middle Aged; Pathogenesis; Prospective Studies; Proton Pump Inhibitors - pharmacology; Proton Pump Inhibitors - therapeutic use; Regression analysis; Remission (Medicine); Treatment Outcome; Young Adult
• ISSN: 0002-9270; 1572-0241; 1572-0241
• DOI: 10.14309/ajg.0000000000000379

Role of reflux and mechanisms of response to proton pump inhibitor (PPI) therapy in eosinophilic esophagitis (EoE) have not yet been fully elucidated. Comprehensive assessment by impedance-pH monitoring could clarify these issues. Prospective multicenter study comparing EoE patients with healthy con...