Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer

• Published in: Cancer science Vol. 110; no. 5; pp. 1510 - 1517
• Main Authors: Hayashi, Yoshihiro, Yokota, Asumi, Harada, Hironori, Huang, Gang
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2019; John Wiley and Sons Inc
• Subjects: Biosynthesis; Cancer; Carcinoma; Cell adhesion & migration; Cell Hypoxia; Enzymes; Gene expression; Gene Expression Regulation, Neoplastic; Glucose; Glucose metabolism; Glycolysis; HIF1A; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - chemistry; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Kinases; Lactic Acid - metabolism; Metabolism; Metastases; Mutation; Neoplasms - genetics; Neoplasms - metabolism; oncometabolite; Phosphorylation; Protein Stability; Proteins; pseudohypoxia; Pyruvic Acid - metabolism; Review; Signal Transduction; Tumors; Warburg effect; Warburg, Otto; pseudohypoxia; hypoxia; oncometabolite; HIF1A; Warburg effect

Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia has been known as a central hallmark of cancer cells and their microenvironment. Indeed, hypoxia benefits cancer cells in their growth, survival, and metastasis. The historical discovery of hypoxia‐induci...