The effect of synbiotic supplementation on anthropometric indices, appetite, and constipation in people with hypothyroidism: A randomized, double‐blind, placebo‐controlled trial
Abstarct Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation...
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| Published in | Phytotherapy research Vol. 34; no. 10; pp. 2712 - 2720 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.10.2020
Wiley Subscription Services, Inc |
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| Online Access | Get full text |
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| Abstract | Abstarct
Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation on anthropometric indices, appetite, and constipation in subjects with hypothyroidism. Sixty subjects with hypothyroidism were assigned into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) per day for 8 weeks. Anthropometric indices, appetite, and constipation were assessed at study baseline and end of the trial. At the end of trial, waist‐to‐hip ratio was significantly decreased in the synbiotic group (p = .030), whereas there were no significant differences between groups. We did not observe any statistically significant change in appetite or other anthropometric indices (p > .05). Compared with the placebo synbiotic supplementation led to a significant reduction in constipation (p = .048). The results of the present trial indicated that synbiotic supplementation may have favorable results in constipation among subjects with hypothyroidism for 8 weeks. Further studies with larger sample size and longer duration are needed to confirm our findings. |
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| AbstractList | AbstarctHypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation on anthropometric indices, appetite, and constipation in subjects with hypothyroidism. Sixty subjects with hypothyroidism were assigned into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) per day for 8 weeks. Anthropometric indices, appetite, and constipation were assessed at study baseline and end of the trial. At the end of trial, waist‐to‐hip ratio was significantly decreased in the synbiotic group (p = .030), whereas there were no significant differences between groups. We did not observe any statistically significant change in appetite or other anthropometric indices (p > .05). Compared with the placebo synbiotic supplementation led to a significant reduction in constipation (p = .048). The results of the present trial indicated that synbiotic supplementation may have favorable results in constipation among subjects with hypothyroidism for 8 weeks. Further studies with larger sample size and longer duration are needed to confirm our findings. Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation on anthropometric indices, appetite, and constipation in subjects with hypothyroidism. Sixty subjects with hypothyroidism were assigned into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) per day for 8 weeks. Anthropometric indices, appetite, and constipation were assessed at study baseline and end of the trial. At the end of trial, waist‐to‐hip ratio was significantly decreased in the synbiotic group (p = .030), whereas there were no significant differences between groups. We did not observe any statistically significant change in appetite or other anthropometric indices (p > .05). Compared with the placebo synbiotic supplementation led to a significant reduction in constipation (p = .048). The results of the present trial indicated that synbiotic supplementation may have favorable results in constipation among subjects with hypothyroidism for 8 weeks. Further studies with larger sample size and longer duration are needed to confirm our findings. Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation on anthropometric indices, appetite, and constipation in subjects with hypothyroidism. Sixty subjects with hypothyroidism were assigned into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) per day for 8 weeks. Anthropometric indices, appetite, and constipation were assessed at study baseline and end of the trial. At the end of trial, waist-to-hip ratio was significantly decreased in the synbiotic group (p = .030), whereas there were no significant differences between groups. We did not observe any statistically significant change in appetite or other anthropometric indices (p > .05). Compared with the placebo synbiotic supplementation led to a significant reduction in constipation (p = .048). The results of the present trial indicated that synbiotic supplementation may have favorable results in constipation among subjects with hypothyroidism for 8 weeks. Further studies with larger sample size and longer duration are needed to confirm our findings.Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation on anthropometric indices, appetite, and constipation in subjects with hypothyroidism. Sixty subjects with hypothyroidism were assigned into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) per day for 8 weeks. Anthropometric indices, appetite, and constipation were assessed at study baseline and end of the trial. At the end of trial, waist-to-hip ratio was significantly decreased in the synbiotic group (p = .030), whereas there were no significant differences between groups. We did not observe any statistically significant change in appetite or other anthropometric indices (p > .05). Compared with the placebo synbiotic supplementation led to a significant reduction in constipation (p = .048). The results of the present trial indicated that synbiotic supplementation may have favorable results in constipation among subjects with hypothyroidism for 8 weeks. Further studies with larger sample size and longer duration are needed to confirm our findings. Abstarct Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation on anthropometric indices, appetite, and constipation in subjects with hypothyroidism. Sixty subjects with hypothyroidism were assigned into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) per day for 8 weeks. Anthropometric indices, appetite, and constipation were assessed at study baseline and end of the trial. At the end of trial, waist‐to‐hip ratio was significantly decreased in the synbiotic group (p = .030), whereas there were no significant differences between groups. We did not observe any statistically significant change in appetite or other anthropometric indices (p > .05). Compared with the placebo synbiotic supplementation led to a significant reduction in constipation (p = .048). The results of the present trial indicated that synbiotic supplementation may have favorable results in constipation among subjects with hypothyroidism for 8 weeks. Further studies with larger sample size and longer duration are needed to confirm our findings. |
| Author | Heidari, Zahra Mohammadi, Hamed Asbaghi, Omid Hadi, Amir Marx, Wolfgang Askari, Gholamreza Talebi, Sepide Karimifar, Mozhgan |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32363616$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1053/j.gastro.2010.01.053 10.1038/nature11552 10.7453/gahmj.2014.018 10.3390/microorganisms7030068 10.1111/obr.12626 10.1016/j.clnu.2012.08.010 10.3109/00365521.2011.584895 10.4103/2008-7802.178533 10.1007/s10151-014-1201-5 10.2337/db11-1019 10.1159/000342994 10.1038/nrgastro.2013.146 10.1016/j.appet.2013.02.017 10.3109/09637486.2013.775224 10.1111/obr.12541 10.33073/pjm-2015-014 10.1016/j.jnutbio.2017.08.006 10.4103/2230-8210.183454 10.1017/S0007114514000919 10.1530/EJE-19-0666 10.1038/sj.ijo.0801083 10.1016/j.clnu.2013.03.004 10.3389/fendo.2017.00316 10.1080/20786204.2012.10874256 10.1016/j.ctim.2019.102234 10.1080/10408398.2018.1458021 10.1002/9781118874905 10.1089/thy.2012.0205 10.1080/19390211.2018.1455788 10.1016/j.clnu.2018.09.033 10.1080/09637486.2016.1181156 10.1097/MCG.0000000000001064 10.1210/jc.2007-0606 10.1016/j.ctim.2019.05.008 10.24926/iip.v10i3.2026 10.1007/s12020-014-0509-2 |
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| References | 2012; 61 2019; 7 2017; 8 2010; 16 2013; 66 2000; 24 2019; 10 2019; 59 2013; 64 2020; 182 2019; 16 2019; 38 2007; 92 2005 2018; 60 2012; 489 2012; 54 2014; 112 2017; 50 2018; 19 2016; 7 2015; 49 2014; 3 2012; 1 2013; 32 2013; 10 2019; 44 2010; 138 2015; 64 2016; 20 2019 2018 2020; 48 2018; 52 2011; 46 2017; 18 2014; 18 2011; 141 2012; 22 2016; 67 e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_34_1 e_1_2_9_10_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_12_1 e_1_2_9_33_1 Talebi S. (e_1_2_9_35_1) 2019 Chmielewska A. (e_1_2_9_8_1) 2010; 16 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_37_1 e_1_2_9_19_1 e_1_2_9_41_1 e_1_2_9_42_1 e_1_2_9_20_1 Fateh R. (e_1_2_9_11_1) 2011; 141 Hussain Z. (e_1_2_9_18_1) 2019; 16 e_1_2_9_40_1 e_1_2_9_22_1 e_1_2_9_21_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_23_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 e_1_2_9_9_1 e_1_2_9_26_1 Hadi A. (e_1_2_9_16_1) 2018; 60 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_27_1 e_1_2_9_29_1 |
| References_xml | – volume: 16 start-page: 69 issue: 1 year: 2010 end-page: 75 article-title: Systematic review of randomised controlled trials: Probiotics for functional constipation publication-title: World Journal of Gastroenterology – volume: 8 start-page: 316 year: 2017 article-title: Probiotics ingestion does not directly affect thyroid hormonal parameters in hypothyroid patients on levothyroxine treatment publication-title: Frontiers in Endocrinology – volume: 64 start-page: 687 issue: 6 year: 2013 end-page: 693 article-title: The effects of synbiotic supplementation on some cardio‐metabolic risk factors in overweight and obese children: A randomized triple‐masked controlled trial publication-title: International Journal of Food Sciences and Nutrition – volume: 38 start-page: 2031 issue: 5 year: 2019 end-page: 2037 article-title: Do probiotics, prebiotics and synbiotics affect adiponectin and leptin in adults? A systematic review and meta‐analysis of clinical trials publication-title: Clinical Nutrition – volume: 54 start-page: 384 issue: 5 year: 2012 end-page: 390 article-title: Hypothyroidism: An update publication-title: South African Family Practice – year: 2005 – volume: 489 start-page: 242 issue: 7415 year: 2012 end-page: 249 article-title: Functional interactions between the gut microbiota and host metabolism publication-title: Nature – volume: 18 start-page: 832 issue: 8 year: 2017 end-page: 851 article-title: Weight‐loss interventions and gut microbiota changes in overweight and obese patients: A systematic review publication-title: Obesity Reviews – volume: 59 start-page: 2494 issue: 15 year: 2019 end-page: 2505 article-title: Efficacy of synbiotic supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of clinical trials: Synbiotic supplementation and NAFLD publication-title: Critical Reviews in Food Science and Nutrition – volume: 182 start-page: 11 year: 2020 end-page: 21 article-title: Prevalence of endocrine disorders in obese patients: Systematic review and meta‐analysis publication-title: European Journal of Endocrinology – volume: 32 start-page: 27 issue: 1 year: 2013 end-page: 33 article-title: Effect of synbiotic in constipated adult women—a randomized, double‐blind, placebo‐controlled study of clinical response publication-title: Clinical Nutrition – volume: 61 start-page: 364 issue: 2 year: 2012 end-page: 371 article-title: Short‐chain fatty acids stimulate glucagon‐like peptide‐1 secretion via the G‐protein‐coupled receptor FFAR2 publication-title: Diabetes – volume: 112 start-page: 438 issue: 3 year: 2014 end-page: 445 article-title: Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: A randomised, double‐blind, placebo‐controlled pilot study publication-title: British Journal of Nutrition – volume: 67 start-page: 571 issue: 5 year: 2016 end-page: 580 article-title: Effect of probiotics on body weight and body‐mass index: A systematic review and meta‐analysis of randomized, controlled trials publication-title: International Journal of Food Sciences and Nutrition – volume: 66 start-page: 44 year: 2013 end-page: 53 article-title: Gut hormone release and appetite regulation in healthy non‐obese participants following oligofructose intake. A Dose‐Escalation Study publication-title: Appetite – volume: 16 start-page: 294 issue: 3 year: 2019 end-page: 306 article-title: The effects of synbiotic supplementation on body mass index, metabolic and inflammatory biomarkers, and appetite in patients with metabolic syndrome: A triple‐blind randomized controlled trial publication-title: Journal of Dietary Supplements – volume: 16 start-page: 205 year: 2019 end-page: 210 article-title: Undetected hypothyroidism and its anesthetic implications publication-title: Anaesthesia, Pain & Intensive Care – volume: 60 start-page: 1 year: 2018 end-page: 13 article-title: Efficacy of synbiotic supplementation in obesity treatment: A systematic review and meta‐analysis of clinical trials publication-title: Critical Reviews in Food Science and Nutrition – year: 2018 – start-page: 1 year: 2019 end-page: 14 article-title: Trace element status and hypothyroidism: A systematic review and meta‐analysis publication-title: Biological Trace Element Research – volume: 10 start-page: 19 issue: 3 year: 2019 end-page: 19 article-title: Hypothyroid symptoms in levothyroxine‐treated patients publication-title: Innovations in Pharmacy – volume: 138 start-page: 1772 issue: 5 year: 2010 end-page: 1782 article-title: Short‐chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats publication-title: Gastroenterology – volume: 92 start-page: 4180 issue: 11 year: 2007 end-page: 4184 article-title: Association between hypothyroidism and small intestinal bacterial overgrowth publication-title: The Journal of Clinical Endocrinology & Metabolism – volume: 44 start-page: 269 year: 2019 end-page: 276 article-title: Effects of pro‐/synbiotic supplementation on anthropometric and metabolic indices in overweight or obese children and adolescents: A systematic review and meta‐analysis publication-title: Complementary Therapies in Medicine – volume: 7 start-page: 59 year: 2016 article-title: The effect of symbiotic supplementation on liver enzymes, C‐reactive protein and ultrasound findings in patients with non‐alcoholic fatty liver disease: A clinical trial publication-title: International Journal of Preventive Medicine – volume: 19 start-page: 219 issue: 2 year: 2018 end-page: 232 article-title: Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: A systematic review and meta‐analysis of randomized controlled trials publication-title: Obesity Reviews – volume: 22 start-page: 1200 issue: 12 year: 2012 end-page: 1235 article-title: Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association publication-title: Thyroid – volume: 1 start-page: 159 issue: 3 year: 2012 end-page: 167 article-title: Thyroid function and obesity publication-title: European Thyroid Journal – volume: 64 issue: 2 year: 2015 article-title: Intestinal microbiota, obesity and prebiotics publication-title: Polish Journal of Microbiology – volume: 48 year: 2020 article-title: The effects of synbiotic supplementation on thyroid function and inflammation in hypothyroid patients: A randomized, double‐blind, placebo‐controlled trial publication-title: Complementary Therapies in Medicine – volume: 52 start-page: S50 year: 2018 end-page: S56 article-title: Influence of probiotics administration on gut microbiota core: A review on the effects on appetite control, glucose, and lipid metabolism publication-title: Journal of Clinical Gastroenterology – volume: 3 start-page: 44 issue: 3 year: 2014 end-page: 57 article-title: The role of the gut microbiome in the pathogenesis and treatment of obesity publication-title: Global Advances in Health and Medicine – volume: 141 year: 2011 article-title: Synbiotic preparation in men suffering from functional constipation: A randomised controlled trial publication-title: Swiss Medical Weekly – volume: 18 start-page: 945 issue: 10 year: 2014 end-page: 953 article-title: Effect of a new synbiotic supplement on symptoms, stool consistency, intestinal transit time and gut microbiota in patients with severe functional constipation: A pilot randomized double‐blind, controlled trial publication-title: Techniques in Coloproctology – volume: 46 start-page: 1057 issue: 9 year: 2011 end-page: 1064 article-title: Dose–response effect of HN019 on whole gut transit time and functional gastrointestinal symptoms in adults publication-title: Scandinavian Journal of Gastroenterology – volume: 20 start-page: 554 issue: 4 year: 2016 end-page: 557 article-title: Hypothyroidism and obesity: An intriguing link publication-title: Indian Journal of Endocrinology and Metabolism – volume: 7 start-page: 68 issue: 3 year: 2019 article-title: Microbial population changes and their relationship with human health and disease publication-title: Microorganisms – volume: 24 start-page: 38 issue: 1 year: 2000 end-page: 48 article-title: Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies publication-title: International Journal of Obesity – volume: 10 start-page: 637 issue: 11 year: 2013 end-page: 644 article-title: The Gordian Knot of dysbiosis, obesity and NAFLD publication-title: Nature Reviews Gastroenterology & Hepatology – volume: 49 start-page: 583 issue: 3 year: 2015 end-page: 587 article-title: Does microbiota composition affect thyroid homeostasis? publication-title: Endocrine – volume: 50 start-page: 16 year: 2017 end-page: 25 article-title: Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice publication-title: The Journal of Nutritional Biochemistry – volume: 32 start-page: 928 issue: 6 year: 2013 end-page: 934 article-title: Efficacy of microbial cell preparation in improving chronic constipation: A randomized, double‐blind, placebo‐controlled trial publication-title: Clinical Nutrition – ident: e_1_2_9_33_1 doi: 10.1053/j.gastro.2010.01.053 – volume: 141 start-page: w13239 year: 2011 ident: e_1_2_9_11_1 article-title: Synbiotic preparation in men suffering from functional constipation: A randomised controlled trial publication-title: Swiss Medical Weekly – ident: e_1_2_9_38_1 doi: 10.1038/nature11552 – ident: e_1_2_9_26_1 doi: 10.7453/gahmj.2014.018 – ident: e_1_2_9_2_1 doi: 10.3390/microorganisms7030068 – ident: e_1_2_9_7_1 doi: 10.1111/obr.12626 – ident: e_1_2_9_41_1 doi: 10.1016/j.clnu.2012.08.010 – ident: e_1_2_9_42_1 doi: 10.3109/00365521.2011.584895 – ident: e_1_2_9_3_1 doi: 10.4103/2008-7802.178533 – ident: e_1_2_9_6_1 doi: 10.1007/s10151-014-1201-5 – ident: e_1_2_9_37_1 doi: 10.2337/db11-1019 – volume: 60 start-page: 1 year: 2018 ident: e_1_2_9_16_1 article-title: Efficacy of synbiotic supplementation in obesity treatment: A systematic review and meta‐analysis of clinical trials publication-title: Critical Reviews in Food Science and Nutrition – ident: e_1_2_9_21_1 doi: 10.1159/000342994 – ident: e_1_2_9_24_1 doi: 10.1038/nrgastro.2013.146 – ident: e_1_2_9_27_1 doi: 10.1016/j.appet.2013.02.017 – ident: e_1_2_9_30_1 doi: 10.3109/09637486.2013.775224 – ident: e_1_2_9_32_1 doi: 10.1111/obr.12541 – ident: e_1_2_9_5_1 doi: 10.33073/pjm-2015-014 – start-page: 1 year: 2019 ident: e_1_2_9_35_1 article-title: Trace element status and hypothyroidism: A systematic review and meta‐analysis publication-title: Biological Trace Element Research – ident: e_1_2_9_19_1 – ident: e_1_2_9_4_1 doi: 10.1016/j.jnutbio.2017.08.006 – volume: 16 start-page: 205 year: 2019 ident: e_1_2_9_18_1 article-title: Undetected hypothyroidism and its anesthetic implications publication-title: Anaesthesia, Pain & Intensive Care – ident: e_1_2_9_31_1 doi: 10.4103/2230-8210.183454 – ident: e_1_2_9_9_1 doi: 10.1017/S0007114514000919 – ident: e_1_2_9_39_1 doi: 10.1530/EJE-19-0666 – ident: e_1_2_9_12_1 doi: 10.1038/sj.ijo.0801083 – ident: e_1_2_9_20_1 doi: 10.1016/j.clnu.2013.03.004 – ident: e_1_2_9_34_1 doi: 10.3389/fendo.2017.00316 – ident: e_1_2_9_14_1 doi: 10.1080/20786204.2012.10874256 – volume: 16 start-page: 69 issue: 1 year: 2010 ident: e_1_2_9_8_1 article-title: Systematic review of randomised controlled trials: Probiotics for functional constipation publication-title: World Journal of Gastroenterology – ident: e_1_2_9_36_1 doi: 10.1016/j.ctim.2019.102234 – ident: e_1_2_9_17_1 doi: 10.1080/10408398.2018.1458021 – ident: e_1_2_9_23_1 doi: 10.1002/9781118874905 – ident: e_1_2_9_15_1 doi: 10.1089/thy.2012.0205 – ident: e_1_2_9_28_1 doi: 10.1080/19390211.2018.1455788 – ident: e_1_2_9_29_1 doi: 10.1016/j.clnu.2018.09.033 – ident: e_1_2_9_43_1 doi: 10.1080/09637486.2016.1181156 – ident: e_1_2_9_10_1 doi: 10.1097/MCG.0000000000001064 – ident: e_1_2_9_22_1 doi: 10.1210/jc.2007-0606 – ident: e_1_2_9_25_1 doi: 10.1016/j.ctim.2019.05.008 – ident: e_1_2_9_13_1 doi: 10.24926/iip.v10i3.2026 – ident: e_1_2_9_40_1 doi: 10.1007/s12020-014-0509-2 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Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss... Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of... AbstarctHypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss... |
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| SubjectTerms | anorexia Anthropometry appetite Appetite loss Body measurements Constipation Double-blind studies duration Hypothyroidism incidence Obesity people phytotherapy placebos sample size Statistical analysis Supplements synbiotic waist-to-hip ratio weight gain |
| Title | The effect of synbiotic supplementation on anthropometric indices, appetite, and constipation in people with hypothyroidism: A randomized, double‐blind, placebo‐controlled trial |
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