Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF‐1α‐induced pro‐angiogenic factor - Wang, Ji‐Chang; Li, Xiong‐Xiong; Sun, Xin; Li, Guang‐Yue; Sun, Jing‐Lan; Ye, Yuan‐Peng; Cong, Long‐Long; Li, Wei‐Ming; Lu, Shao‐Ying; Feng, Jun; Liu, Pei‐Jun (Cancer science, 2018)
Keywords: AMP; AMP-Activated Protein Kinases - antagonists & inhibitors; AMP-Activated Protein Kinases - physiology; AMPK; Angiogenesis; Animals; Antibodies; anti‐angiogenesis; Breast cancer; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug dosages; Endothelial cells; Enzyme Activation - drug effects; Female; Fibroblast Growth Factor 2 - analysis; Fibroblast growth factors; HIF‐1α; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit - physiology; Kinases; Lectins; Medical research; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic - prevention & control; Original; Phosphorylation; Proteins; Simvastatin; Simvastatin - pharmacology; Smooth muscle; statin; Statins; Statistical analysis; Transcription; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - analysis; United States--US; simvastatin; AMPK; HIF-1α; statin; anti-angiogenesis