The application of flux balance analysis in systems biology

• Published in: Wiley interdisciplinary reviews. Systems biology and medicine Vol. 2; no. 3; p. 372
• Main Authors: Gianchandani, Erwin P, Chavali, Arvind K, Papin, Jason A
• Format: Journal Article
• Language: English
• Published: United States 01.05.2010
• Subjects: Algorithms; Animals; Computer Simulation; Energy Metabolism - physiology; Energy Transfer - physiology; Humans; Models, Biological; Protein Interaction Mapping - methods; Proteome - metabolism; Signal Transduction - physiology; Systems Biology - methods; Thermodynamics

An increasing number of genome-scale reconstructions of intracellular biochemical networks are being generated. Coupled with these stoichiometric models, several systems-based approaches for probing these reconstructions in silico have been developed. One such approach, called flux balance analysis...