How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo

• Published in: Critical care medicine Vol. 40; no. 9; p. 2609
• Main Authors: Ramakers, Bart P, Wever, Kimberley E, Kox, Matthijs, van den Broek, Petra H, Mbuyi, Faustin, Rongen, Gerard, Masereeuw, Rosalinde, van der Hoeven, Johannes G, Smits, Paul, Riksen, Niels P, Pickkers, Peter
• Format: Journal Article
• Language: English
• Published: United States 01.09.2012
• Subjects: Adenosine - analysis; Adenosine - metabolism; Analysis of Variance; Cells, Cultured; Cytokines - metabolism; Down-Regulation; Endotoxemia - blood; Endotoxemia - metabolism; Endotoxins; Gene Expression Regulation; Human Experimentation; Humans; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - metabolism; Lipopolysaccharides - pharmacology; Lymphocytes; Male; Real-Time Polymerase Chain Reaction; Receptors, Purinergic P1 - genetics; Receptors, Purinergic P1 - metabolism; Reference Values; RNA, Messenger - analysis; Sampling Studies; Systemic Inflammatory Response Syndrome - metabolism; Systemic Inflammatory Response Syndrome - physiopathology; Young Adult

Adenosine modulates inflammation and prevents associated organ injury by activation of its receptors. During sepsis, the extracellular adenosine concentration increases rapidly, but the underlying mechanism in humans is unknown. We aimed to determine the changes in adenosine metabolism and signaling...