Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure–activity relationships
A wide series of synthetic flavonoids, with druglikeness properties, were developed and evaluated as antitumoral agents against TK-10, MCF-7, and HT-29 human tumoral cells. Comet assay was performed against non-tumoral HK-2 in order to know chromosomal aberrations in normal cells. A QSAR was obtaine...
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Published in | Bioorganic & medicinal chemistry Vol. 15; no. 10; pp. 3356 - 3367 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
15.05.2007
Elsevier Science |
Subjects | |
Online Access | Get full text |
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