Ventricular Arrhythmia Substrate Distribution and Its Relation to Sympathetic Innervation in Nonischemic Cardiomyopathy Patients

• Published in: JACC. Clinical electrophysiology Vol. 8; no. 10; pp. 1234 - 1245
• Main Authors: Chen, H. Sophia, Jungen, Christiane, Kimura, Yoshitaka, Dibbets-Schneider, Petra, Piers, Sebastiaan R., Androulakis, Alexander F.A., van der Geest, Rob J., de Geus-Oei, Lioe-Fee, Scholte, Arthur J.H.A., Lamb, Hildo J., Jongbloed, Monique R.M., Zeppenfeld, Katja
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2022
• Subjects: arrhythmogenicity; autonomic nervous system; dilated cardiomyopathy; electroanatomic voltage mapping; sympathetic denervation; ventricular tachycardia; NICM; IHD; LVEF; LV; arrhythmogenicity; SPECT; ILS; dilated cardiomyopathy; 123I MIBG; ASS; UV; autonomic nervous system; electroanatomic voltage mapping; LGE-CMR; CMR; sympathetic denervation; LGE; VA; HMR; 3D; EAVM; ventricular tachycardia; RF; RFCA; VT

Nonischemic cardiomyopathy patients referred for catheter ablation of ventricular arrhythmias (VAs) typically have either inferolateral (ILS) or anteroseptal (ASS) VA substrate locations, with poorer outcomes for ASS. Sympathetic denervation is an important determinant of arrhythmogenicity. Its rela...