Validation of a biomarker panel in Barrett's esophagus to predict progression to esophageal adenocarcinoma

• Published in: Diseases of the esophagus Vol. 31; no. 11
• Main Authors: Eluri, S, Klaver, E, Duits, L C, Jackson, S A, Bergman, J J, Shaheen, N J
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.11.2018
• Subjects: Adenocarcinoma - genetics; Aged; Area Under Curve; Barrett Esophagus - complications; Barrett Esophagus - genetics; Barrett Esophagus - pathology; Biomarkers, Tumor - genetics; Biopsy; Case-Control Studies; Disease Progression; DNA Mutational Analysis; Esophageal Neoplasms - genetics; Esophagus - pathology; Female; Humans; Hyperplasia - genetics; Loss of Heterozygosity; Male; Microsatellite Instability; Middle Aged; Neoplasm Proteins - analysis; Predictive Value of Tests; Rapid Review; Reference Values; Risk Assessment - statistics & numerical data; ROC Curve

In a prior study, baseline mutational load (ML) predicted progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE) with an area under the curve (AUC) of 0.95. We aimed to validate the test characteristics of this predictive biomarker panel using c...