Nuclear compensatory evolution driven by mito-nuclear incompatibilities

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 42; p. e2411672121
• Main Authors: Princepe, Debora, de Aguiar, Marcus A. M.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 15.10.2024
• Subjects: Animals; Biological Evolution; Biological Sciences; Cell Nucleus - genetics; Cell Nucleus - metabolism; Coevolution; Compatibility; Compensation; Deoxyribonucleic acid; DNA; DNA, Mitochondrial - genetics; Evolution; Evolution, Molecular; Evolutionary genetics; Fecundity; Genes; Genomes; Interspecific hybridization; Mitochondria - genetics; Mitochondria - metabolism; Mitochondrial DNA; Models, Genetic; Mutation; Mutation Rate; Mutation rates; Population genetics; Radiation; Selection, Genetic; Speciation; mitochondrial mutation rate; mito-nuclear coevolution; nuclear compensation; mtDNA introgression

Mitochondrial function relies on the coordinated expression of mitochondrial and nuclear genes, exhibiting remarkable resilience despite high mitochondrial mutation rates. The nuclear compensation mechanism suggests deleterious mitochondrial alleles drive compensatory nuclear mutations to preserve m...