Association of IL-6, IL-8, MMP-13 gene polymorphisms with knee osteoarthritis susceptibility in the Chinese Han population

• Published in: Bioscience reports Vol. 39; no. 2
• Main Authors: Sun, Gang, Ba, Cheng-Lei, Gao, Ren, Liu, Wenqing, Ji, Qiang
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 28.02.2019
• Subjects: Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group - genetics; Case-Control Studies; Female; Gene Expression; Gene Frequency; Genetic Predisposition to Disease; Humans; Interleukin-6 - genetics; Interleukin-8 - genetics; Male; Matrix Metalloproteinase 13 - genetics; Middle Aged; Mutation; Osteoarthritis, Knee - etiology; Osteoarthritis, Knee - genetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; RNA, Messenger; Single nucleotide polymorphism; Interleukin-8; Osteoarthritis; Matrix metalloproteinase-13; Interleukin-6

Objective: To identify the association between the interleukin (IL) 6 (IL-6) rs1800795 (-174 G>C), IL-8 rs4073 (-251T>A), and matrix metalloproteinase-13 (MMP-13) rs2252070 (-77G>A) gene polymorphisms and knee osteoarthritis (KOA) susceptibility in the Chinese Han population. Methods: Genom...