A Single Nucleotide Polymorphism in the Vitamin D Receptor Gene Is Associated With Decreased Levels of the Protein and a Penetrating Pattern in Crohn's Disease

• Published in: Inflammatory bowel diseases Vol. 24; no. 7; pp. 1462 - 1470
• Main Authors: Gisbert-Ferrándiz, Laura, Salvador, Pedro, Ortiz-Masiá, Dolores, Macías-Ceja, Dulce Carolina, Orden, Samuel, Esplugues, Juan Vicente, Calatayud, Sara, Hinojosa, Joaquín, Barrachina, Maria Dolores, Hernández, Carlos
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 08.06.2018
• Subjects: Crohn's disease; Polymerase chain reaction; Polymorphism; Proteins; Vitamin D; single-nucleotide polymorphisms; penetrating behavior; vitamin D receptor

Abstract Background Vitamin D signaling modulates inflammation through the vitamin D receptor (VDR). The synonymous single nucleotide polymorphism (SNP) rs731236, located in the VDR gene, has been associated with a higher risk of Crohn's disease (CD). We analyzed differences in VDR expression l...