TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB
TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes. Both TRAIL receptors bind the adaptor molecules FADD and TRADD, and b...
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| Published in | Immunity (Cambridge, Mass.) Vol. 7; no. 6; pp. 831 - 836 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.12.1997
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| Online Access | Get full text |
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| Abstract | TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes. Both TRAIL receptors bind the adaptor molecules FADD and TRADD, and both death signals are interrupted by a dominant negative form of FADD and by the FLICE-inhibitory protein FLIP. The recruitment of TRADD may explain the potent activation of NF- Kappa B observed by TRAIL receptors. Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. |
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| AbstractList | TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes. Both TRAIL receptors bind the adaptor molecules FADD and TRADD, and both death signals are interrupted by a dominant negative form of FADD and by the FLICE-inhibitory protein FLIP. The recruitment of TRADD may explain the potent activation of NF- Kappa B observed by TRAIL receptors. Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. |
| Author | Bodmer, Jean-Luc Thome, Margot Kataoka, Takao Burns, Kim Schneider, Pascal Hofmann, Kay Holler, Nils Tschopp, Jürg |
| Author_xml | – sequence: 1 givenname: Pascal surname: Schneider fullname: Schneider, Pascal – sequence: 2 givenname: Margot surname: Thome fullname: Thome, Margot – sequence: 3 givenname: Kim surname: Burns fullname: Burns, Kim – sequence: 4 givenname: Jean-Luc surname: Bodmer fullname: Bodmer, Jean-Luc – sequence: 5 givenname: Kay surname: Hofmann fullname: Hofmann, Kay – sequence: 6 givenname: Takao surname: Kataoka fullname: Kataoka, Takao – sequence: 7 givenname: Nils surname: Holler fullname: Holler, Nils – sequence: 8 givenname: Jürg surname: Tschopp fullname: Tschopp, Jürg |
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| References | Yu (10.1016/S1074-7613(00)80401-X_BIB30) 1996; 274 Srinivasula (10.1016/S1074-7613(00)80401-X_BIB25) 1997; 272 Pan (10.1016/S1074-7613(00)80401-X_BIB16) 1997; 277 Pitti (10.1016/S1074-7613(00)80401-X_BIB18) 1996; 271 Thome (10.1016/S1074-7613(00)80401-X_BIB27) 1997; 386 Chinnaiyan (10.1016/S1074-7613(00)80401-X_BIB4) 1995; 81 Marsters (10.1016/S1074-7613(00)80401-X_BIB12) 1996; 6 Shu (10.1016/S1074-7613(00)80401-X_BIB23) 1997; 6 Tartaglia (10.1016/S1074-7613(00)80401-X_BIB26) 1993; 74 Hu (10.1016/S1074-7613(00)80401-X_BIB7) 1997; 272 Wiley (10.1016/S1074-7613(00)80401-X_BIB29) 1995; 3 Boldin (10.1016/S1074-7613(00)80401-X_BIB3) 1995; 270 Smith (10.1016/S1074-7613(00)80401-X_BIB24) 1994; 76 Schneider (10.1016/S1074-7613(00)80401-X_BIB20) 1997; 272 Chinnaiyan (10.1016/S1074-7613(00)80401-X_BIB5) 1996; 271 Pan (10.1016/S1074-7613(00)80401-X_BIB17) 1997; 276 Bertin (10.1016/S1074-7613(00)80401-X_BIB1) 1997; 94 Hu (10.1016/S1074-7613(00)80401-X_BIB8) 1997; 272 Nicholson (10.1016/S1074-7613(00)80401-X_BIB15) 1997; 8 Dhein (10.1016/S1074-7613(00)80401-X_BIB6) 1995; 96 Kitson (10.1016/S1074-7613(00)80401-X_BIB11) 1996; 384 Kischkel (10.1016/S1074-7613(00)80401-X_BIB10) 1995; 14 Nagata (10.1016/S1074-7613(00)80401-X_BIB14) 1997; 88 Walczak (10.1016/S1074-7613(00)80401-X_BIB28) 1997; 16 Irmler (10.1016/S1074-7613(00)80401-X_BIB9) 1997; 388 Marsters (10.1016/S1074-7613(00)80401-X_BIB13) 1996; 6 Sheridan (10.1016/S1074-7613(00)80401-X_BIB22) 1997; 277 Bodmer (10.1016/S1074-7613(00)80401-X_BIB2) 1997; 6 Sambrook (10.1016/S1074-7613(00)80401-X_BIB19) 1989 Schneider (10.1016/S1074-7613(00)80401-X_BIB21) 1997; 416 |
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