Interlaboratory agreement of insulin-like growth factor 1 concentrations measured by mass spectrometry

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 60; no. 3; pp. 541 - 548
• Main Authors: Cox, Holly D, Lopes, Filipe, Woldemariam, Getachew A, Becker, Jessica O, Parkin, Mark C, Thomas, Andreas, Butch, Anthony W, Cowan, David A, Thevis, Mario, Bowers, Larry D, Hoofnagle, Andrew N
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2014
• Subjects: Acromegaly - blood; Calibration; Case-Control Studies; Chromatography; Chromatography, Liquid - standards; Humans; Immunoassay - standards; Immunoassays; Instrumentation; Insulin-Like Growth Factor I - analysis; Insulin-Like Growth Factor I - standards; Insulin-like growth factors; Laboratories; Mass spectrometry; Sample preparation; Tandem Mass Spectrometry - instrumentation; Tandem Mass Spectrometry - standards

Insulin-like growth factor 1 (IGF-1)(7) is a key mediator of growth hormone (GH) action and a well-characterized biomarker of GH abuse. Current immunoassays for IGF-1 suffer from poor concordance between platforms, which makes comparison of results between laboratories difficult. Although previous w...