Meibum Lipidomic Analysis in Evaporative Dry Eye Subjects

• Published in: International journal of molecular sciences Vol. 25; no. 9; p. 4782
• Main Authors: Garcia-Queiruga, Jacobo, Pena-Verdeal, Hugo, Sabucedo-Villamarin, Belen, Paz-Tarrio, Monica, Guitian-Fernandez, Esteban, Garcia-Resua, Carlos, Yebra-Pimentel, Eva, Giraldez, Maria J.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2024
• Subjects: Adult; Aged; Analysis; Boxes; Chromatography; Dry Eye Syndromes - metabolism; Female; Humans; Instrument industry; Lipid Metabolism; Lipidomics - methods; Lipids; Lipids - analysis; Male; Meibomian Gland Dysfunction - metabolism; Meibomian Glands - metabolism; Middle Aged; Morphology; Tears - chemistry; Tears - metabolism; Massachusetts; Japan; Spain; eyelid margin abnormalities; meibum; lipid layer pattern; meibomian gland; tear film lipid layer

Meibomian Glands (MG) are sebaceous glands responsible for the production of meibum, the main component of the Tear Film Lipid Layer (TFLL). The TFLL facilitates the spread of the tear film over the ocular surface, provides stability and reduces tear evaporation. Alterations in meibum composition le...