Ovarian tumors orchestrate distinct cellular compositions

The determinants of T cell infiltration in tumors remain largely unknown. In a recent issue of Cancer Cell, Hornburg et al. use single-cell RNA sequencing to characterize the cellular compartments of the ovarian cancer microenvironment and shed light on how tumor, immune, and stromal cells interact...

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Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 54; no. 6; pp. 1107 - 1109
Main Authors Bou-Tayeh, Berna, Miller, Martin L
Format Journal Article
LanguageEnglish
Published United States Elsevier Limited 08.06.2021
Subjects
Cancer
Chemokines
Chemotherapy
Cytokines
Cytotoxicity
Female
Gene expression
Gene sequencing
Humans
Immunotherapy
Infiltration
Ligands
Lymphocytes
Lymphocytes T
Lymphocytes, Tumor-Infiltrating
Metastases
Microenvironments
Ovarian cancer
Ovarian Neoplasms
Sequence Analysis, RNA
Stromal Cells
Tumor Microenvironment
Tumors
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Summary:The determinants of T cell infiltration in tumors remain largely unknown. In a recent issue of Cancer Cell, Hornburg et al. use single-cell RNA sequencing to characterize the cellular compartments of the ovarian cancer microenvironment and shed light on how tumor, immune, and stromal cells interact and shape T cell infiltration.
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SourceType-Scholarly Journals-1
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ObjectType-Commentary-3
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2021.05.014