Compositional Flux Within the Intestinal Microbiota and Risk for Bloodstream Infection With Gram-negative Bacteria

• Published in: Clinical infectious diseases Vol. 73; no. 11; pp. e4627 - e4635
• Main Authors: Stoma, Igor, Littmann, Eric R, Peled, Jonathan U, Giralt, Sergio, van den Brink, Marcel R M, Pamer, Eric G, Taur, Ying
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 06.12.2021
• Subjects: Bacteremia - microbiology; Gastrointestinal Microbiome; Gram-Negative Bacteria; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Online Only; Retrospective Studies; Sepsis - complications; intestinal microbiota; gram-negative bloodstream infections; allogeneic hematopoietic cell transplantation

Gram-negative bloodstream infections (BSIs) represent a significant complication facing allogeneic hematopoietic cell transplant (allo-HCT) recipients, as a result of intestinal translocation during neutropenia. In this study we sought to better understand how the composition of the intestinal micro...