Obesity Appears to Be Associated With Altered Muscle Protein Synthetic and Breakdown Responses to Increased Nutrient Delivery in Older Men, but Not Reduced Muscle Mass or Contractile Function

• Published in: Diabetes (New York, N.Y.) Vol. 64; no. 9; pp. 3160 - 3171
• Main Authors: Murton, Andrew J, Marimuthu, Kanagaraj, Mallinson, Joanne E, Selby, Anna L, Smith, Kenneth, Rennie, Michael J, Greenhaff, Paul L
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.09.2015
• Subjects: Adipokines - metabolism; Adipose Tissue - metabolism; Aged; Amino Acids - pharmacology; Atrophy; Body mass index; Case-Control Studies; Exercise; Gene Expression Profiling; Glucose Clamp Technique; Humans; Hypoglycemic Agents - pharmacology; Inflammation; Insulin - pharmacology; Leg; Male; Middle Aged; Muscle Contraction; Muscle Proteins - biosynthesis; Muscle Proteins - drug effects; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Obesity; Obesity - genetics; Obesity - immunology; Obesity - metabolism; Older people; Protein synthesis; RNA, Messenger - metabolism

Obesity is increasing, yet despite the necessity of maintaining muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ± 1.1 kg · m(-2)) and 15 healthy-weight (BMI 23.4 ± 0.3 kg · m(-2)) older men (55-75 years old)...