Decreased Synovial Fluid Biomarkers Levels Are Associated with Rehabilitation of Function and Pain in Rotator Cuff Tear Patients Following Electroacupuncture Therapy
BACKGROUND The aim of this study was to assess inflammatory cytokines levels in synovial fluid (SF) before and after electroacupuncture (EA) treatment and to explore whether these biomarkers are associated with function of rotator cuff tear (RCT) patients. MATERIAL AND METHODS We recruited 54 patien...
Saved in:
Published in | Medical science monitor Vol. 26; p. e923240 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
International Scientific Literature, Inc
11.09.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | BACKGROUND The aim of this study was to assess inflammatory cytokines levels in synovial fluid (SF) before and after electroacupuncture (EA) treatment and to explore whether these biomarkers are associated with function of rotator cuff tear (RCT) patients. MATERIAL AND METHODS We recruited 54 patients with RCT and separated them into an EA group and a control group. The SF biomarker levels were detected at baseline and at 6-week and 6-month follow-up. The symptomatic severity was evaluated by visual analog scale (VAS), Constant-Murley score, and American Shoulder and Elbow Surgeons score (ASES). We also investigated the correlation between symptomatic severity and biomarker levels in SF of the shoulder joint. RESULTS The reductions in VAS and improved functional score (ASES and Constant-Murley score) were significantly different between the 2 groups, and SF biomarker concentrations were significantly lower in the EA group. IL-1ß levels were significantly negatively correlated with Constant-Murley score (r=-0.73, P=0.04) and ASES score (r=-0.59, P<0.001) and positively correlated with VAS scores (r=0.81, P=0.004). IL-6 levels were significantly negatively correlated with Constant-Murley score (r=-0.67, P=0.03) and positively correlated with VAS score (r=0.7, P=0.01). MMP-1 levels were significantly negatively correlated with ASES score (r=-0.57, P<0.001). CONCLUSIONS The biomarkers in SF were directly associated with shoulder pain and shoulder function in rotator cuff tear. EA, as a safe and effective conservative therapy, obviously decreased the level of inflammatory cytokines in RCT patients, accompanied by a reduction in shoulder pain and improved function. |
---|---|
AbstractList | BACKGROUND The aim of this study was to assess inflammatory cytokines levels in synovial fluid (SF) before and after electroacupuncture (EA) treatment and to explore whether these biomarkers are associated with function of rotator cuff tear (RCT) patients. MATERIAL AND METHODS We recruited 54 patients with RCT and separated them into an EA group and a control group. The SF biomarker levels were detected at baseline and at 6-week and 6-month follow-up. The symptomatic severity was evaluated by visual analog scale (VAS), Constant-Murley score, and American Shoulder and Elbow Surgeons score (ASES). We also investigated the correlation between symptomatic severity and biomarker levels in SF of the shoulder joint. RESULTS The reductions in VAS and improved functional score (ASES and Constant-Murley score) were significantly different between the 2 groups, and SF biomarker concentrations were significantly lower in the EA group. IL-1ß levels were significantly negatively correlated with Constant-Murley score (r=-0.73, P=0.04) and ASES score (r=-0.59, P<0.001) and positively correlated with VAS scores (r=0.81, P=0.004). IL-6 levels were significantly negatively correlated with Constant-Murley score (r=-0.67, P=0.03) and positively correlated with VAS score (r=0.7, P=0.01). MMP-1 levels were significantly negatively correlated with ASES score (r=-0.57, P<0.001). CONCLUSIONS The biomarkers in SF were directly associated with shoulder pain and shoulder function in rotator cuff tear. EA, as a safe and effective conservative therapy, obviously decreased the level of inflammatory cytokines in RCT patients, accompanied by a reduction in shoulder pain and improved function. |
Author | Geng, Wei-Qiang Liu, You-Jie Wang, Huajun Zheng, Xiao-Fei Guan, Jian Li, Yao Ding, Luo-Bin Xue, Wei Liu, Guang-Yuan |
AuthorAffiliation | 4 Department of Orthopedics, Handan Central Hospital, Handan, Hebei, P.R. China 3 Department of Orthopedic Surgery and Sports Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, P.R. China 1 Department of Orthopedic Surgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China 2 Department of Orthopedic Surgery, No. 980 Hospital, Joint Logistics Support Force People’s Liberation Army (PLA), Handan Campus of Bethune International Hospital, Handan, Hebei, P.R. China |
AuthorAffiliation_xml | – name: 3 Department of Orthopedic Surgery and Sports Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, P.R. China – name: 1 Department of Orthopedic Surgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, P.R. China – name: 2 Department of Orthopedic Surgery, No. 980 Hospital, Joint Logistics Support Force People’s Liberation Army (PLA), Handan Campus of Bethune International Hospital, Handan, Hebei, P.R. China – name: 4 Department of Orthopedics, Handan Central Hospital, Handan, Hebei, P.R. China |
Author_xml | – sequence: 1 givenname: Jian surname: Guan fullname: Guan, Jian organization: Department of Orthopedic Surgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China (mainland) – sequence: 2 givenname: Wei-Qiang surname: Geng fullname: Geng, Wei-Qiang organization: Department of Orthopedic Surgery, No. 980 Hospital, Joint Logistics Support Force People's Liberation Army (PLA), Handan Campus of Bethune International Hospital, Handan, Hebei, China (mainland) – sequence: 3 givenname: Yao surname: Li fullname: Li, Yao organization: Department of Orthopedic Surgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China (mainland) – sequence: 4 givenname: Guang-Yuan surname: Liu fullname: Liu, Guang-Yuan organization: Department of Orthopedic Surgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China (mainland) – sequence: 5 givenname: Luo-Bin surname: Ding fullname: Ding, Luo-Bin organization: Department of Orthopedic Surgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China (mainland) – sequence: 6 givenname: You-Jie surname: Liu fullname: Liu, You-Jie organization: Department of Orthopedic Surgery and Sports Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China (mainland) – sequence: 7 givenname: Wei surname: Xue fullname: Xue, Wei organization: Department of Orthopedics, Handan Central Hospital, Handan, Hebei, China (mainland) – sequence: 8 givenname: Huajun surname: Wang fullname: Wang, Huajun organization: Department of Orthopedic Surgery and Sports Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China (mainland) – sequence: 9 givenname: Xiao-Fei surname: Zheng fullname: Zheng, Xiao-Fei organization: Department of Orthopedic Surgery and Sports Medicine Center, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China (mainland) |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32915775$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkVtrGzEQhUVJaS7tU9-LHgvFqVZa7eWl4DpxW3BISdxnMSvNxmplyZF2HfyD8j-rxmlIYGAOzMeZYc4xOfDBIyHvC3Za8Eq2ny-uL05bLnjJXpGjoirFRNSSHTzTh-Q4pd-M8aZi8g05FLwtZF3LI3J_hjoiJDT0eufD1oKjczdaQ7_asIb4B2OiC9yiS3QakU5TCtrCkPk7O6zoFa6gs84OMNjgaejpfPT6QYM39CdYT3NdhQyESGdj39MlQsyTwaIfEp0H58Kd9Tf03KEeYgA9bv55jHndcoURNru35HUPLuG7x35Cfs3Pl7Pvk8Xltx-z6WKiRVMMk05q2fNClw0Dpg1A07KmlGi6rgPZy7oQveayqTQ3daGz7iphRNMa02lomTghX_a-m7Fbo9H5wAhObaLNr9ipAFa9nHi7Ujdhq_KP67qts8HHR4MYbkdMg1rbpNE58BjGpHhZcs6aWrYZ_bRHdQwpReyf1hRMPQSrcrBqH2ymPzy_7In9n6T4C-bbpX4 |
CitedBy_id | crossref_primary_10_12998_wjcc_v12_i21_4582 crossref_primary_10_3389_fneur_2024_1342844 crossref_primary_10_1016_j_cvsm_2022_02_003 crossref_primary_10_1002_msc_1719 |
ContentType | Journal Article |
Copyright | Med Sci Monit, 2020 2020 |
Copyright_xml | – notice: Med Sci Monit, 2020 2020 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
DOI | 10.12659/MSM.923240 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1643-3750 |
EndPage | e923240 |
ExternalDocumentID | 10_12659_MSM_923240 32915775 |
Genre | Clinical Trial Journal Article |
GroupedDBID | --- 3EA 5GY ABMXE ADBBV ADRAZ AEGXH AENEX ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL CGR CUY CVF E3Z ECM EIF EMOBN F5P GX1 HYE KQ8 M48 M~E NPM OK1 PGMZT RPM SJN SV3 XSB 2WC 53G AAKDD AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c381t-b5c5f21c480a0cdaa890845edbbba5f5713fc2586c2d71cfc2b63d389ddbca903 |
IEDL.DBID | RPM |
ISSN | 1643-3750 1234-1010 |
IngestDate | Tue Sep 17 21:27:31 EDT 2024 Fri Aug 16 10:23:07 EDT 2024 Fri Aug 23 04:00:35 EDT 2024 Sat Sep 28 08:27:07 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | true |
Language | English |
License | This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c381t-b5c5f21c480a0cdaa890845edbbba5f5713fc2586c2d71cfc2b63d389ddbca903 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Funds Collection Jian Guan and Wei-Qiang Geng contributed equally to this work Data Interpretation Literature Search Data Collection Study Design Manuscript Preparation Statistical Analysis |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507797/ |
PMID | 32915775 |
PQID | 2442208759 |
PQPubID | 23479 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7507797 proquest_miscellaneous_2442208759 crossref_primary_10_12659_MSM_923240 pubmed_primary_32915775 |
PublicationCentury | 2000 |
PublicationDate | 2020-09-11 |
PublicationDateYYYYMMDD | 2020-09-11 |
PublicationDate_xml | – month: 09 year: 2020 text: 2020-09-11 day: 11 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Medical science monitor |
PublicationTitleAlternate | Med Sci Monit |
PublicationYear | 2020 |
Publisher | International Scientific Literature, Inc |
Publisher_xml | – name: International Scientific Literature, Inc |
SSID | ssj0028605 |
Score | 2.3502975 |
Snippet | BACKGROUND The aim of this study was to assess inflammatory cytokines levels in synovial fluid (SF) before and after electroacupuncture (EA) treatment and to... |
SourceID | pubmedcentral proquest crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | e923240 |
SubjectTerms | Biomarkers - metabolism Clinical Research Cytokines - analysis Electroacupuncture Female Humans Inflammation Male Middle Aged Recovery of Function - physiology Rotator Cuff Injuries - rehabilitation Synovial Fluid - immunology |
SummonAdditionalLinks | – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhhZBL6bvbFyrk6tSWJcs6lNKmMaHUpSS7kJvRkyykdrpet80P6v_sjB9LNu2p4INAD4O_Gc031miGkINgE6DFVkfGJj7iXoNK5YpFWSq1kFoyH-Pd4fJLdrLgn87F-Q6ZinGOH7D9p2uH9aQWq8vDX9-v34HCv-1zI2RCvSnPykOF1AB89zuMpxxFveSb4wSWDxckYZfmsO8k8XhR79bkfbKXMpUIiUGHN63UX9TzdgTlDZNU3CN3Ry5J3w_g3yc7vn5A9srxtPwh-f2x54Std_Tsum5-gKjR4rJbOvph2XzDuJxVSz9j1FALi3g6QQXj8fcsPd3K4k2bQAuwgn1b145-1cuawnParNFzp0ddCHQOmgM9fbLWlhYgZc1PsI70eCi3o213hWt08Lr5kNDgEVkUx_Ojk2gsyxBZMO_ryAgrAkssz2MdW6d1ruKcC--MMVoEAW5vsEzkmWVOJhbaJksdECPnjNUqTh-T3bqp_VNCdWqlEtJwZxVXscqdjK2wQSmXOaHCjBxMMFRXQ_aNCr0WBK4C4KoBuBl5PUFUgXbgkYeufdO1FZAXxjBpv5qRJwNkm4UmrGdEboG5GYCZt7d76uVFn4EbaJaUSj7775nPyT5Dxx1rUSQvyO561fmXwG7W5lUvuX8AxZf-Pg priority: 102 providerName: Scholars Portal |
Title | Decreased Synovial Fluid Biomarkers Levels Are Associated with Rehabilitation of Function and Pain in Rotator Cuff Tear Patients Following Electroacupuncture Therapy |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32915775 https://search.proquest.com/docview/2442208759 https://pubmed.ncbi.nlm.nih.gov/PMC7507797 |
Volume | 26 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBbZHEovpe9u2gYVcvWuLVuWdWy3MaHUJSQbyM1II5kasvISrxvyg_o_O_IjZNtbwQeBZNnwjTTfSPMg5KSCCGkxqEBDZIPEKlxSmWRBGgvFhRLMhj52uPiRnl0l36759QHhUyxM77QPul64m83C1T9738rtBpaTn9jyvFihlhNCiuWMzEQcTyb6aGVlQzAk7sgJ7jFROAblsZTLZXFZLKTnEL4AXMxkxIV3MHyskf6hmX97Sz5SP_lz8mzkjfTz8H8vyIF1L8mTYrwZf0V-f-35X2sNvbx3zS8UK5rfdLWhX-pm431wblv63XsItTiJpRMsON4fxdKLvYzdtKlojhqvbytn6LmqHcXnotl5K52uuqqia1wl2NMnZm1pjhLV3KEmpKdDaR0F3dbP0eHn1kPygtfkKj9dr86CsQRDAKjKd4HmwCsWQZKFKgSjVCbDLOHWaK0VrziauBUwnqXAjIgA2zqNDZIgYzQoGcZvyKFrnH1HqIpBSC50YkAmMpSZESFwqKQ0qeGympOTCYZyO2TaKL2F4oErEbhyAG5OPk0QlbgS_PWGcrbp2hKJCmM-Qb-ck7cDZA8TTVjPidgD82GAz7K934PC12fbHoXt6L_ffE-eMm-k-7oT0QdyuLvt7EdkMjt9TGZFkh338vsHzir43g |
link.rule.ids | 230,315,733,786,790,891,24346,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb5wwELbSVGpz6bvN9ulKucKCwRgf023Qtl2iKNlUuSG_UFGzsArQKP0_-Z8d84iy6amVOFiyMaCZYb6xZz4jtJcrH2CxEo5UvnFCI8CkYk6cKGCCMsGI8WztcHoYzU_Dr2f0bAvRsRamS9pXsnDL85VbFj-63Mr1Sk3HPLHpUToDL8cYZ9N76D7YK6FjkD7EWXFfDgn_5BD-Mr43lOWRiPJpepK63KIIewRcQLhPmU0xvO2T_gKad_Mlbzmg5DH6Pr56n3fy020b6arfd1gd__nbnqBHAyTF-333U7RlymfoQTpsuj9H1587aFkbjU-uyuoXaCxOzttC409FtbLpPRc1XtjkoxomMXiUOIy3q7z4eIMMHFc5TsCZdm1RanwkihLDdVw1dgEAz9o8x0swQOjpOF9rnICyVpfgZPFBf2qPUO3aztHC45Y9L8ILdJocLGdzZzjdwVGAEhpHUkVz4qsw9oSntBAx9-KQGi2lFDSnED3nitA4UkQzX0FbRoEGfKW1VIJ7wUu0XVal2UVYBIpxymSoFQ-5x2PNPEVVzrmONOX5BO2N8s3WPYlHZoMfqxEZaETWa8QEfRxln4GR2Z0TUZqqrTPAQIRY7n8-Qa96XbiZaFSiCWIbWnIzwBJ4b_aA7Dsi70HWr__7zg_o4XyZLrLFl8Nvb9AOsWsB9ngL_y3abi5a8w4AUyPfd-bxB1lkGhM |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagSBWX8oYtLyP1mpcTx_ERto0KNNWq3UoVl8iPWER0k1WTgOD_8D8Z51HtllulHCzFcRLNjOcb-_MMQgdGBQCLlXCkCgonKgSYVMKJE4dMUCYYKXx7djg7jY8voi-X9HKj1FdP2leydKurlVuV33tu5XqlvIkn5i2yOXg5xjjz1tp499EDsFnCpkB9jLWS4UgkzMsRzDSBPx7NIzHlXnaeudwiCVsGLiQ8oMzSDDf90n9g8zZncsMJpY_Qt-nzB-7JD7drpav-3MrseKf_e4z2RmiKPw5dnqB7RfUU7Wbj5vsz9Pewh5hNofH576r-CZqL06uu1PhTWa8szee6wSeWhNTAIAWeJA_97WovPttKCo5rg1Nwqn1bVBovRFlhuM7q1i4E4HlnDF6CIcKdPvdrg1NQ2voXOFt8NFTvEapb2zE6eN1yyI_wHF2kR8v5sTNWeXAUoIXWkVRRQwIVJb7wlRYi4X4S0UJLKQU1FKJoowhNYkU0CxS0ZRxqwFlaSyW4H75AO1VdFa8QFqFinDIZacUj7vNEM19RZTjXsabczNDBJON8PSTzyG0QZLUiB63IB62YoQ-T_HMwNruDIqqi7pocsBAhtgYAn6GXgz7cDDQp0gyxLU256WATeW_fAfn3Cb1Hee_f-cn3aHdxmOYnn0-_vkYPiV0SsFUugjdop73uireAm1r5rreQfwWyHJM |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Decreased+Synovial+Fluid+Biomarkers+Levels+Are+Associated+with+Rehabilitation+of+Function+and+Pain+in+Rotator+Cuff+Tear+Patients+Following+Electroacupuncture+Therapy&rft.jtitle=Medical+science+monitor&rft.au=Guan%2C+Jian&rft.au=Geng%2C+Wei-Qiang&rft.au=Li%2C+Yao&rft.au=Liu%2C+Guang-Yuan&rft.date=2020-09-11&rft.pub=International+Scientific+Literature%2C+Inc&rft.issn=1234-1010&rft.eissn=1643-3750&rft.volume=26&rft.spage=e923240-1&rft.epage=e923240-10&rft_id=info:doi/10.12659%2FMSM.923240&rft_id=info%3Apmid%2F32915775&rft.externalDBID=PMC7507797 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1643-3750&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1643-3750&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1643-3750&client=summon |