Lagomorphs (rabbits, pikas and hares) do not use telomere-directed replicative aging in vitro

• Published in: Mechanisms of ageing and development Vol. 126; no. 6; pp. 685 - 691
• Main Authors: Forsyth, Nicholas R., Elder, Frederick F.B., Shay, Jerry W., Wright, Woodring E.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.06.2005; Elsevier Science
• Subjects: Aging; Animals; Biological and medical sciences; Cells, Cultured; Cellular Senescence - physiology; Development. Metamorphosis. Moult. Ageing; Fundamental and applied biological sciences. Psychology; Hares - physiology; Lagomorpha; Rabbits; Senescence; Telomerase; Telomerase - metabolism; Telomere; Telomere - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Aging; Rabbits; Senescence; Lagomorpha; Telomere; Telomerase; Vertebrata; Mammalia; Enzyme; Ageing; Rabbit; In vitro

Telomere shortening is used for replicative aging in primates and ungulates but not rodents. We examined telomere biology in rabbits to expand the comparative biology of telomere-directed replicative senescence within mammals. The order Lagomorpha consists of two families; Leporidae and Ochotonidae....