Repetitive transcranial magnetic stimulation of primary motor cortex for stroke upper limb motor sequelae rehabilitation: A systematic review

Repetitive Transcranial Magnetic Stimulation (rTMS) over the primary motor cortex (M1) has been used to treat stroke motor sequelae regulating cortical excitability. Early interventions are widely recommended, but there is also evidence showing interventions in subacute or chronic phases are still u...

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Published inNeuroRehabilitation (Reading, Mass.) Vol. 52; no. 3; pp. 329 - 348
Main Authors Sánchez-Cuesta, Francisco José, González-Zamorano, Yeray, Arroyo-Ferrer, Aída, Moreno-Verdú, Marcos, Romero-Muñoz, Juan Pablo
Format Journal Article
LanguageEnglish
Published Netherlands IOS Press BV 01.01.2023
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Abstract Repetitive Transcranial Magnetic Stimulation (rTMS) over the primary motor cortex (M1) has been used to treat stroke motor sequelae regulating cortical excitability. Early interventions are widely recommended, but there is also evidence showing interventions in subacute or chronic phases are still useful. To synthetize the evidence of rTMS protocols to improve upper limb motor function in people with subacute and/or chronic stroke. Four databases were searched in July 2022. Clinical trials investigating the effectiveness of different rTMS protocols on upper limb motor function in subacute or chronic phases post-stroke were included. PRISMA guidelines and PEDro scale were used. Thirty-two studies representing 1137 participants were included. Positive effects of all types of rTMS protocols on upper limb motor function were found. These effects were heterogeneous and not always clinically relevant or related to neurophysiological changes but produced evident changes if evaluated with functional tests. rTMS interventions over M1 are effective for improving upper limb motor function in people with subacute and chronic stroke. When rTMS protocols were priming physical rehabilitation better effects were achieved. Studies considering minimal clinical differences and different dosing will help to generalize the use of these protocols in clinical practice.
AbstractList Repetitive Transcranial Magnetic Stimulation (rTMS) over the primary motor cortex (M1) has been used to treat stroke motor sequelae regulating cortical excitability. Early interventions are widely recommended, but there is also evidence showing interventions in subacute or chronic phases are still useful. To synthetize the evidence of rTMS protocols to improve upper limb motor function in people with subacute and/or chronic stroke. Four databases were searched in July 2022. Clinical trials investigating the effectiveness of different rTMS protocols on upper limb motor function in subacute or chronic phases post-stroke were included. PRISMA guidelines and PEDro scale were used. Thirty-two studies representing 1137 participants were included. Positive effects of all types of rTMS protocols on upper limb motor function were found. These effects were heterogeneous and not always clinically relevant or related to neurophysiological changes but produced evident changes if evaluated with functional tests. rTMS interventions over M1 are effective for improving upper limb motor function in people with subacute and chronic stroke. When rTMS protocols were priming physical rehabilitation better effects were achieved. Studies considering minimal clinical differences and different dosing will help to generalize the use of these protocols in clinical practice.
BACKGROUNDRepetitive Transcranial Magnetic Stimulation (rTMS) over the primary motor cortex (M1) has been used to treat stroke motor sequelae regulating cortical excitability. Early interventions are widely recommended, but there is also evidence showing interventions in subacute or chronic phases are still useful. OBJECTIVETo synthetize the evidence of rTMS protocols to improve upper limb motor function in people with subacute and/or chronic stroke. METHODSFour databases were searched in July 2022. Clinical trials investigating the effectiveness of different rTMS protocols on upper limb motor function in subacute or chronic phases post-stroke were included. PRISMA guidelines and PEDro scale were used. RESULTSThirty-two studies representing 1137 participants were included. Positive effects of all types of rTMS protocols on upper limb motor function were found. These effects were heterogeneous and not always clinically relevant or related to neurophysiological changes but produced evident changes if evaluated with functional tests. CONCLUSIONrTMS interventions over M1 are effective for improving upper limb motor function in people with subacute and chronic stroke. When rTMS protocols were priming physical rehabilitation better effects were achieved. Studies considering minimal clinical differences and different dosing will help to generalize the use of these protocols in clinical practice.
BACKGROUND: Repetitive Transcranial Magnetic Stimulation (rTMS) over the primary motor cortex (M1) has been used to treat stroke motor sequelae regulating cortical excitability. Early interventions are widely recommended, but there is also evidence showing interventions in subacute or chronic phases are still useful. OBJECTIVE: To synthetize the evidence of rTMS protocols to improve upper limb motor function in people with subacute and/or chronic stroke. METHODS: Four databases were searched in July 2022. Clinical trials investigating the effectiveness of different rTMS protocols on upper limb motor function in subacute or chronic phases post-stroke were included. PRISMA guidelines and PEDro scale were used. RESULTS: Thirty-two studies representing 1137 participants were included. Positive effects of all types of rTMS protocols on upper limb motor function were found. These effects were heterogeneous and not always clinically relevant or related to neurophysiological changes but produced evident changes if evaluated with functional tests. CONCLUSION: rTMS interventions over M1 are effective for improving upper limb motor function in people with subacute and chronic stroke. When rTMS protocols were priming physical rehabilitation better effects were achieved. Studies considering minimal clinical differences and different dosing will help to generalize the use of these protocols in clinical practice.
Author Romero-Muñoz, Juan Pablo
Arroyo-Ferrer, Aída
González-Zamorano, Yeray
Sánchez-Cuesta, Francisco José
Moreno-Verdú, Marcos
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Cites_doi 10.1523/JNEUROSCI.0222-09.2009
10.12786/bn.2021.14.e6
10.1161/STROKEAHA.108.522144
10.1002/ana.21725
10.1016/S1474-4422(04)00851-8
10.1097/PHM.0b013e31813e0de0
10.1054/math.2000.0372
10.1093/ptj/83.8.713
10.1016/S1474-4422(03)00321-1
10.1177/1545968315593804
10.1080/08990220.2017.1316254
10.3389/fneur.2022.940467
10.3233/RNN-160669
10.1055/s-0038-1649503
10.1016/S0924-980X(97)00052-0
10.1177/1545968321992330
10.1177/1545968312437940
10.1016/j.apmr.2013.10.023
10.1016/j.biopsych.2004.07.017
10.1161/01.STR.30.12.2666
10.3109/17483107.2012.737136
10.3233/RNN-140460
10.1161/STROKEAHA.111.000522
10.1161/01.STR.0000221233.55497.51
10.1177/11795735211072731
10.2340/16501977-0181
10.1186/s12984-021-00885-5
10.1155/2019/7084618
10.3233/RNN-130313
10.2340/16501977-0454
10.1073/pnas.2026676118
10.1177/0269215519829897
10.1111/cns.12221
10.1161/01.STR.0000012515.66889.24
10.1161/01.STR.0000231390.58967.6b
10.1155/2012/359728
10.1161/STROKEAHA.110.583278
10.1002/oti.1403
10.3233/RNN-130358
10.1016/j.jstrokecerebrovasdis.2021.105795
10.1161/STROKEAHA.121.037870
10.1212/WNL.0b013e3182436558
10.1016/j.brs.2015.06.007
10.1177/0269215517692386
10.1155/2022/9455428
10.3389/fnhum.2015.00349
10.1155/2014/305236
10.1016/j.clinph.2019.11.002
10.1016/j.clinph.2007.11.049
10.1136/bmj.n71
10.1161/STROKEAHA.117.020607
10.1212/01.WNL.0000161839.38079.92
10.2340/16501977-1175
10.3233/NRE-141191
10.1371/journal.pone.0149026
10.1016/S1474-4422(06)70525-7
10.1016/j.clinph.2009.08.016
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Keywords Repetitive transcranial magnetic stimulation
motor cortex
subacute
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References Dromerick (10.3233/NRE-220306_ref18) 2021; 118
10.3233/NRE-220306_ref12
Zhang (10.3233/NRE-220306_ref60) 2022; 53
Carey (10.3233/NRE-220306_ref8) 2014; 32
Chen (10.3233/NRE-220306_ref11) 2022; 13
Hordacre (10.3233/NRE-220306_ref26) 2021; 35
Bembenek (10.3233/NRE-220306_ref7) 2012; 27
10.3233/NRE-220306_ref50
Kobayashi (10.3233/NRE-220306_ref34) 2003; 2
Di Lazzaro (10.3233/NRE-220306_ref16) 2008; 119
Cassidy (10.3233/NRE-220306_ref10) 2015; 8
Lefaucheur (10.3233/NRE-220306_ref38) 2020; 131
Lang (10.3233/NRE-220306_ref37) 2004; 56
Barros Galvão (10.3233/NRE-220306_ref5) 2014; 95
Maher (10.3233/NRE-220306_ref39) 2003; 83
Hummel (10.3233/NRE-220306_ref27) 2006; 5
Huynh (10.3233/NRE-220306_ref28) 2016; 30
Rose (10.3233/NRE-220306_ref44) 2014; 2014
Mansur (10.3233/NRE-220306_ref41) 2005; 64
Kim (10.3233/NRE-220306_ref33) 2006; 37
Demirtas-Tatlidede (10.3233/NRE-220306_ref15) 2015; 36
10.3233/NRE-220306_ref9
Pennisi (10.3233/NRE-220306_ref43) 1999; 30
Ackerley (10.3233/NRE-220306_ref1) 2010; 41
Yozbatiran (10.3233/NRE-220306_ref59) 2009; 40
Sung (10.3233/NRE-220306_ref48) 2013; 44
Fregni (10.3233/NRE-220306_ref21) 2006; 37
Haghighi (10.3233/NRE-220306_ref22) 2021; 11
Jung (10.3233/NRE-220306_ref29) 2009; 29
Rossi (10.3233/NRE-220306_ref45) 2009; 120
Cho (10.3233/NRE-220306_ref13) 2017; 35
Zhang (10.3233/NRE-220306_ref61) 2017; 31
Sherrington (10.3233/NRE-220306_ref47) 2000; 5
10.3233/NRE-220306_ref32
Malcolm (10.3233/NRE-220306_ref40) 2007; 86
Wang (10.3233/NRE-220306_ref56) 2014; 20
Xiang (10.3233/NRE-220306_ref57) 2019; 33
Askın (10.3233/NRE-220306_ref3) 2017; 34
Hankey (10.3233/NRE-220306_ref23) 2002; 33
Harvey (10.3233/NRE-220306_ref24) 2018; 49
Takeuchi (10.3233/NRE-220306_ref52) 2009; 41
Page (10.3233/NRE-220306_ref42) 2021; 372
Talelli (10.3233/NRE-220306_ref53) 2012; 26
10.3233/NRE-220306_ref49
Katan (10.3233/NRE-220306_ref30) 2018; 38
10.3233/NRE-220306_ref46
Takeuchi (10.3233/NRE-220306_ref51) 2008; 40
Ameli (10.3233/NRE-220306_ref2) 2009; 66
Avenanti (10.3233/NRE-220306_ref4) 2012; 78
Bashir (10.3233/NRE-220306_ref6) 2016; 34
Tretriluxana (10.3233/NRE-220306_ref54) 2013; 8
Yamada (10.3233/NRE-220306_ref58) 2022; 14
Kwon (10.3233/NRE-220306_ref36) 2014; 32
Kim (10.3233/NRE-220306_ref31) 2016; 23
Vongvaivanichakul (10.3233/NRE-220306_ref55) 2014; 97
Hirakawa (10.3233/NRE-220306_ref25) 2018; 25
Dobkin (10.3233/NRE-220306_ref17) 2004; 3
Etoh (10.3233/NRE-220306_ref20) 2013; 45
Kuzu (10.3233/NRE-220306_ref35) 2021; 30
Du (10.3233/NRE-220306_ref19) 2022; 2022
Cicinelli (10.3233/NRE-220306_ref14) 1997; 105
References_xml – volume: 29
  start-page: 5597
  issue: 17
  year: 2009
  ident: 10.3233/NRE-220306_ref29
  article-title: Homeostatic and nonhomeostatic modulation of learning in human motor cortex
  publication-title: The Journal of Neuroscience: The Official Journal of the Society for Neuroscience
  doi: 10.1523/JNEUROSCI.0222-09.2009
  contributor:
    fullname: Jung
– ident: 10.3233/NRE-220306_ref32
  doi: 10.12786/bn.2021.14.e6
– volume: 40
  start-page: 309
  issue: 1
  year: 2009
  ident: 10.3233/NRE-220306_ref59
  article-title: Safety and behavioral effects of high-frequency repetitive transcranial magnetic stimulation in stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.522144
  contributor:
    fullname: Yozbatiran
– volume: 66
  start-page: 298
  issue: 3
  year: 2009
  ident: 10.3233/NRE-220306_ref2
  article-title: Differential effects of high-frequency repetitive transcranial magnetic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke
  publication-title: Annals of Neurology
  doi: 10.1002/ana.21725
  contributor:
    fullname: Ameli
– volume: 3
  start-page: 528
  issue: 9
  year: 2004
  ident: 10.3233/NRE-220306_ref17
  article-title: Strategies for stroke rehabilitation
  publication-title: The Lancet. Neurology
  doi: 10.1016/S1474-4422(04)00851-8
  contributor:
    fullname: Dobkin
– volume: 86
  start-page: 707
  issue: 9
  year: 2007
  ident: 10.3233/NRE-220306_ref40
  article-title: Repetitive transcranial magnetic stimulation as an adjunct to constraint-induced therapy
  publication-title: AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
  doi: 10.1097/PHM.0b013e31813e0de0
  contributor:
    fullname: Malcolm
– volume: 5
  start-page: 223
  issue: 4
  year: 2000
  ident: 10.3233/NRE-220306_ref47
  article-title: PEDro. A database of randomized trials and systematic reviews in physiotherapy
  publication-title: Manual Therapy
  doi: 10.1054/math.2000.0372
  contributor:
    fullname: Sherrington
– volume: 97
  start-page: S45
  issue: Suppl 7
  year: 2014
  ident: 10.3233/NRE-220306_ref55
  article-title: Reach-to-grasp training in individuals with chronic stroke augmented by low-frequency repetitive transcranial magnetic stimulation
  publication-title: Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
  contributor:
    fullname: Vongvaivanichakul
– volume: 83
  start-page: 713
  issue: 8
  year: 2003
  ident: 10.3233/NRE-220306_ref39
  article-title: Reliability of the PEDro scale for rating quality of randomized controlled trials
  publication-title: Physical Therapy
  doi: 10.1093/ptj/83.8.713
  contributor:
    fullname: Maher
– volume: 2
  start-page: 145
  issue: 3
  year: 2003
  ident: 10.3233/NRE-220306_ref34
  article-title: Transcranial magnetic stimulation in neurology
  publication-title: The Lancet. Neurology
  doi: 10.1016/S1474-4422(03)00321-1
  contributor:
    fullname: Kobayashi
– volume: 30
  start-page: 244
  issue: 3
  year: 2016
  ident: 10.3233/NRE-220306_ref28
  article-title: Exploring the Evolution of Cortical Excitability Following Acute Stroke
  publication-title: Neurorehabilitation and Neural Repair
  doi: 10.1177/1545968315593804
  contributor:
    fullname: Huynh
– volume: 34
  start-page: 102
  issue: 2
  year: 2017
  ident: 10.3233/NRE-220306_ref3
  article-title: Effects of low-frequency repetitive transcranial magnetic stimulation on upper extremity motor recovery and functional outcomes in chronic stroke patients: A randomized controlled trial
  publication-title: Somatosensory & Motor Research
  doi: 10.1080/08990220.2017.1316254
  contributor:
    fullname: Askın
– volume: 13
  start-page: 940467
  year: 2022
  ident: 10.3233/NRE-220306_ref11
  article-title: Effects of repetitive transcranial magnetic stimulation on upper-limb and finger function in stroke patients: A systematic review and meta-analysis of randomized controlled trials
  publication-title: Frontiers in Neurology
  doi: 10.3389/fneur.2022.940467
  contributor:
    fullname: Chen
– volume: 35
  start-page: 105
  issue: 1
  year: 2017
  ident: 10.3233/NRE-220306_ref13
  article-title: Dual-mode noninvasive brain stimulation over the bilateral primary motor cortices in stroke patients
  publication-title: Restorative Neurology and Neuroscience
  doi: 10.3233/RNN-160669
  contributor:
    fullname: Cho
– volume: 38
  start-page: 208
  issue: 2
  year: 2018
  ident: 10.3233/NRE-220306_ref30
  article-title: Global Burden of Stroke
  publication-title: Seminars in Neurology
  doi: 10.1055/s-0038-1649503
  contributor:
    fullname: Katan
– volume: 105
  start-page: 438
  issue: 6
  year: 1997
  ident: 10.3233/NRE-220306_ref14
  article-title: Post-stroke reorganization of brain motor output to the hand: A 2-4 month follow-up with focal magnetic transcranial stimulation
  publication-title: Electroencephalography and Clinical Neurophysiology
  doi: 10.1016/S0924-980X(97)00052-0
  contributor:
    fullname: Cicinelli
– volume: 35
  start-page: 307
  issue: 4
  year: 2021
  ident: 10.3233/NRE-220306_ref26
  article-title: Evidence for a Window of Enhanced Plasticity in the Human Motor Cortex Following Ischemic Stroke
  publication-title: Neurorehabilitation and Neural Repair
  doi: 10.1177/1545968321992330
  contributor:
    fullname: Hordacre
– volume: 26
  start-page: 976
  issue: 8
  year: 2012
  ident: 10.3233/NRE-220306_ref53
  article-title: Theta Burst Stimulation in the Rehabilitation of the Upper Limb: A Semirandomized, Placebo-Controlled Trial in Chronic Stroke Patients
  publication-title: NEUROREHABILITATION AND NEURAL REPAIR
  doi: 10.1177/1545968312437940
  contributor:
    fullname: Talelli
– volume: 95
  start-page: 222
  issue: 2
  year: 2014
  ident: 10.3233/NRE-220306_ref5
  article-title: Efficacy of coupling repetitive transcranial magnetic stimulation and physical therapy to reduce upper-limb spasticity in patients with stroke: A randomized controlled trial
  publication-title: Archives of Physical Medicine and Rehabilitation
  doi: 10.1016/j.apmr.2013.10.023
  contributor:
    fullname: Barros Galvão
– volume: 56
  start-page: 634
  issue: 9
  year: 2004
  ident: 10.3233/NRE-220306_ref37
  article-title: Preconditioning with transcranial direct current stimulation sensitizes the motor cortex to rapid-rate transcranial magnetic stimulation and controls the direction of after-effects
  publication-title: Biological Psychiatry
  doi: 10.1016/j.biopsych.2004.07.017
  contributor:
    fullname: Lang
– volume: 30
  start-page: 2666
  issue: 12
  year: 1999
  ident: 10.3233/NRE-220306_ref43
  article-title: Absence of response to early transcranial magnetic stimulation in ischemic stroke patients: Prognostic value for hand motor recovery
  publication-title: Stroke
  doi: 10.1161/01.STR.30.12.2666
  contributor:
    fullname: Pennisi
– volume: 8
  start-page: 121
  issue: 2
  year: 2013
  ident: 10.3233/NRE-220306_ref54
  article-title: Low frequency repetitive transcranial magnetic stimulation to the non-lesioned hemisphere improves paretic arm reach-to-grasp performance after chronic stroke
  publication-title: Disability and Rehabilitation. Assistive Technology
  doi: 10.3109/17483107.2012.737136
  contributor:
    fullname: Tretriluxana
– volume: 34
  start-page: 677
  issue: 4
  year: 2016
  ident: 10.3233/NRE-220306_ref6
  article-title: Enhanced motor function and its neurophysiological correlates after navigated low-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex in stroke
  publication-title: Restorative Neurology and Neuroscience
  doi: 10.3233/RNN-140460
  contributor:
    fullname: Bashir
– volume: 44
  start-page: 1375
  issue: 5
  year: 2013
  ident: 10.3233/NRE-220306_ref48
  article-title: Efficacy of Coupling Inhibitory and Facilitatory Repetitive Transcranial Magnetic Stimulation to Enhance Motor Recovery in Hemiplegic Stroke Patients
  publication-title: STROKE
  doi: 10.1161/STROKEAHA.111.000522
  contributor:
    fullname: Sung
– volume: 11
  start-page: 175
  issue: 2
  year: 2021
  ident: 10.3233/NRE-220306_ref22
  article-title: The effect of high-frequency repetitive transcranial magnetic stimulation on functional indices of affected upper limb in patients with subacute stroke.. Scopus
  publication-title: Journal of Biomedical Physics and Engineering
  contributor:
    fullname: Haghighi
– volume: 37
  start-page: 1471
  issue: 6
  year: 2006
  ident: 10.3233/NRE-220306_ref33
  article-title: Repetitive transcranial magnetic stimulation-induced corticomotor excitability and associated motor skill acquisition in chronic stroke
  publication-title: Stroke
  doi: 10.1161/01.STR.0000221233.55497.51
  contributor:
    fullname: Kim
– volume: 14
  start-page: 4
  year: 2022
  ident: 10.3233/NRE-220306_ref58
  article-title: Comparison of the effect and treatment sequence between a 2-week parallel repetitive transcranial magnetic stimulation and rehabilitation and a 2-week rehabilitation-only intervention during a 4-week hospitalization for upper limb paralysis after stroke: An open-label, crossover observational study
  publication-title: JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE
  doi: 10.1177/11795735211072731
  contributor:
    fullname: Yamada
– volume: 40
  start-page: 298
  issue: 4
  year: 2008
  ident: 10.3233/NRE-220306_ref51
  article-title: Inhibition of the unaffected motor cortex by Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke
  publication-title: Journal of Rehabilitation Medicine
  doi: 10.2340/16501977-0181
  contributor:
    fullname: Takeuchi
– ident: 10.3233/NRE-220306_ref12
  doi: 10.1186/s12984-021-00885-5
– volume: 27
  start-page: 79
  issue: 2
  year: 2012
  ident: 10.3233/NRE-220306_ref7
  article-title: The prognostic value of motor-evoked potentials in motor recovery and functional outcome after stroke - a systematic review of the literature
  publication-title: Functional Neurology
  contributor:
    fullname: Bembenek
– ident: 10.3233/NRE-220306_ref9
  doi: 10.1155/2019/7084618
– volume: 32
  start-page: 223
  issue: 2
  year: 2014
  ident: 10.3233/NRE-220306_ref36
  article-title: Effective method of combining rTMS and motor training in stroke patients
  publication-title: Restorative Neurology and Neuroscience
  doi: 10.3233/RNN-130313
  contributor:
    fullname: Kwon
– volume: 41
  start-page: 1049
  issue: 13
  year: 2009
  ident: 10.3233/NRE-220306_ref52
  article-title: Repetitive transcranial magnetic stimulation over bilateral hemispheres enhances motor function and training effect of paretic hand in patients after stroke
  publication-title: Journal of Rehabilitation Medicine
  doi: 10.2340/16501977-0454
  contributor:
    fullname: Takeuchi
– volume: 118
  start-page: e2026676118
  issue: 39
  year: 2021
  ident: 10.3233/NRE-220306_ref18
  article-title: Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.2026676118
  contributor:
    fullname: Dromerick
– volume: 33
  start-page: 847
  issue: 5
  year: 2019
  ident: 10.3233/NRE-220306_ref57
  article-title: The effect and optimal parameters of repetitive transcranial magnetic stimulation on motor recovery in stroke patients: A systematic review and meta-analysis of randomized controlled trials
  publication-title: Clinical Rehabilitation
  doi: 10.1177/0269215519829897
  contributor:
    fullname: Xiang
– volume: 20
  start-page: 355
  issue: 4
  year: 2014
  ident: 10.3233/NRE-220306_ref56
  article-title: Differential Effect of Conditioning Sequences in Coupling Inhibitory/Facilitatory Repetitive Transcranial Magnetic Stimulation for PostStroke Motor Recovery
  publication-title: CNS Neuroscience & Therapeutics
  doi: 10.1111/cns.12221
  contributor:
    fullname: Wang
– volume: 33
  start-page: 1034
  issue: 4
  year: 2002
  ident: 10.3233/NRE-220306_ref23
  article-title: Long-term disability after first-ever stroke and related prognostic factors in the Perth Community Stroke Study, 1989-1990
  publication-title: Stroke
  doi: 10.1161/01.STR.0000012515.66889.24
  contributor:
    fullname: Hankey
– volume: 37
  start-page: 2115
  issue: 8
  year: 2006
  ident: 10.3233/NRE-220306_ref21
  article-title: A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients
  publication-title: Stroke
  doi: 10.1161/01.STR.0000231390.58967.6b
  contributor:
    fullname: Fregni
– ident: 10.3233/NRE-220306_ref49
  doi: 10.1155/2012/359728
– volume: 41
  start-page: 1568
  issue: 7
  year: 2010
  ident: 10.3233/NRE-220306_ref1
  article-title: Combining theta burst stimulation with training after subcortical stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.110.583278
  contributor:
    fullname: Ackerley
– volume: 23
  start-page: 39
  issue: 1
  year: 2016
  ident: 10.3233/NRE-220306_ref31
  article-title: Effects of Action Observational Training Plus Brain-Computer Interface-Based Functional Electrical Stimulation on Paretic Arm Motor Recovery in Patient with Stroke: A Randomized Controlled Trial
  publication-title: Occupational Therapy International
  doi: 10.1002/oti.1403
  contributor:
    fullname: Kim
– volume: 32
  start-page: 323
  issue: 2
  year: 2014
  ident: 10.3233/NRE-220306_ref8
  article-title: Serial treatments of primed low-frequency rTMS in stroke: Characteristics of responders vs. Nonresponders
  publication-title: Restorative Neurology and Neuroscience
  doi: 10.3233/RNN-130358
  contributor:
    fullname: Carey
– volume: 30
  start-page: 105795
  issue: 7
  year: 2021
  ident: 10.3233/NRE-220306_ref35
  article-title: The Effect of Sham Controlled Continuous Theta Burst Stimulation and Low Frequency Repetitive Transcranial Magnetic Stimulation on Upper Extremity Spasticity and Functional Recovery in Chronic Ischemic Stroke Patients
  publication-title: Journal of Stroke and Cerebrovascular Diseases
  doi: 10.1016/j.jstrokecerebrovasdis.2021.105795
  contributor:
    fullname: Kuzu
– volume: 53
  start-page: 2171
  issue: 7
  year: 2022
  ident: 10.3233/NRE-220306_ref60
  article-title: Priming Intermittent Theta Burst Stimulation for Hemiparetic Upper Limb After Stroke: A Randomized Controlled Trial
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.121.037870
  contributor:
    fullname: Zhang
– volume: 78
  start-page: 256
  issue: 4
  year: 2012
  ident: 10.3233/NRE-220306_ref4
  article-title: Low-frequency rTMS promotes use-dependent motor plasticity in chronic stroke: A randomized trial
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e3182436558
  contributor:
    fullname: Avenanti
– volume: 8
  start-page: 1074
  issue: 6
  year: 2015
  ident: 10.3233/NRE-220306_ref10
  article-title: A Comparison of Primed Low-frequency Repetitive Transcranial Magnetic Stimulation Treatments in Chronic Stroke
  publication-title: Brain Stimulation
  doi: 10.1016/j.brs.2015.06.007
  contributor:
    fullname: Cassidy
– volume: 31
  start-page: 1137
  issue: 9
  year: 2017
  ident: 10.3233/NRE-220306_ref61
  article-title: Short- and Long-term Effects of Repetitive Transcranial Magnetic Stimulation on Upper Limb Motor Function after Stroke: A Systematic Review and Meta-Analysis
  publication-title: Clinical Rehabilitation
  doi: 10.1177/0269215517692386
  contributor:
    fullname: Zhang
– volume: 2022
  start-page: 9455428
  year: 2022
  ident: 10.3233/NRE-220306_ref19
  article-title: Effects of Neuromuscular Electrical Stimulation Combined with Repetitive Transcranial Magnetic Stimulation on Upper Limb Motor Function Rehabilitation in Stroke Patients with Hemiplegia
  publication-title: Computational and Mathematical Methods in Medicine
  doi: 10.1155/2022/9455428
  contributor:
    fullname: Du
– ident: 10.3233/NRE-220306_ref50
  doi: 10.3389/fnhum.2015.00349
– volume: 2014
  start-page: e305236
  year: 2014
  ident: 10.3233/NRE-220306_ref44
  article-title: Does Inhibitory Repetitive Transcranial Magnetic Stimulation Augment Functional Task Practice to Improve Arm Recovery in Chronic Stroke?
  publication-title: Stroke Research and Treatment
  doi: 10.1155/2014/305236
  contributor:
    fullname: Rose
– volume: 131
  start-page: 474
  issue: 2
  year: 2020
  ident: 10.3233/NRE-220306_ref38
  article-title: Evidence-based guidelines on the therapeutic use of repetitivetranscranial magnetic stimulation (rTMS): An update (2014-2018)
  publication-title: CLINICAL NEUROPHYSIOLOGY
  doi: 10.1016/j.clinph.2019.11.002
  contributor:
    fullname: Lefaucheur
– volume: 119
  start-page: 715
  issue: 3
  year: 2008
  ident: 10.3233/NRE-220306_ref16
  article-title: Modulating cortical excitability in acute stroke: A repetitive TMS study
  publication-title: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
  doi: 10.1016/j.clinph.2007.11.049
  contributor:
    fullname: Di Lazzaro
– volume: 372
  start-page: n71
  year: 2021
  ident: 10.3233/NRE-220306_ref42
  article-title: The PRISMA 2020 statement: An updated guideline for reporting systematicreviews
  publication-title: BMJ
  doi: 10.1136/bmj.n71
  contributor:
    fullname: Page
– volume: 49
  start-page: 2138
  issue: 9
  year: 2018
  ident: 10.3233/NRE-220306_ref24
  article-title: Randomized Sham-Controlled Trial of Navigated Repetitive Transcranial Magnetic Stimulation for Motor Recovery inStroke: The NICHE Trial
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.117.020607
  contributor:
    fullname: Harvey
– volume: 25
  start-page: 321
  issue: 5
  year: 2018
  ident: 10.3233/NRE-220306_ref25
  article-title: Effect of intensive motor training with repetitive transcranial magnetic stimulation on upper limb motor function in chronic post-stroke patients with severe upper limb motor impairment
  publication-title: Topics in Stroke Rehabilitation
  contributor:
    fullname: Hirakawa
– volume: 64
  start-page: 1802
  issue: 10
  year: 2005
  ident: 10.3233/NRE-220306_ref41
  article-title: A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000161839.38079.92
  contributor:
    fullname: Mansur
– volume: 45
  start-page: 843
  issue: 9
  year: 2013
  ident: 10.3233/NRE-220306_ref20
  article-title: Effects of repetitive trascranial magnetic stimulation on repetitive facilitation exercises of the hemiplegic hand in chronic stroke patients
  publication-title: Journal of Rehabilitation Medicine
  doi: 10.2340/16501977-1175
  contributor:
    fullname: Etoh
– volume: 36
  start-page: 51
  issue: 1
  year: 2015
  ident: 10.3233/NRE-220306_ref15
  article-title: Long-term effects of contralesional rTMS in severe stroke: Safety, cortical excitability, and relationship with transcallosal motor fibers
  publication-title: NeuroRehabilitation
  doi: 10.3233/NRE-141191
  contributor:
    fullname: Demirtas-Tatlidede
– ident: 10.3233/NRE-220306_ref46
  doi: 10.1371/journal.pone.0149026
– volume: 5
  start-page: 708
  issue: 8
  year: 2006
  ident: 10.3233/NRE-220306_ref27
  article-title: Non-invasive brain stimulation: A new strategy to improve neurorehabilitation after stroke?
  publication-title: The Lancet. Neurology
  doi: 10.1016/S1474-4422(06)70525-7
  contributor:
    fullname: Hummel
– volume: 120
  start-page: 2008
  issue: 12
  year: 2009
  ident: 10.3233/NRE-220306_ref45
  article-title: Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research
  publication-title: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
  doi: 10.1016/j.clinph.2009.08.016
  contributor:
    fullname: Rossi
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Snippet Repetitive Transcranial Magnetic Stimulation (rTMS) over the primary motor cortex (M1) has been used to treat stroke motor sequelae regulating cortical...
BACKGROUND: Repetitive Transcranial Magnetic Stimulation (rTMS) over the primary motor cortex (M1) has been used to treat stroke motor sequelae regulating...
BACKGROUNDRepetitive Transcranial Magnetic Stimulation (rTMS) over the primary motor cortex (M1) has been used to treat stroke motor sequelae regulating...
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StartPage 329
SubjectTerms Clinical trials
Complications
Cortex (motor)
Excitability
Humans
Magnetic fields
Motor Cortex
Recovery of Function - physiology
Rehabilitation
Stroke
Stroke Rehabilitation - methods
Systematic review
Transcranial magnetic stimulation
Transcranial Magnetic Stimulation - methods
Treatment Outcome
Upper Extremity
Title Repetitive transcranial magnetic stimulation of primary motor cortex for stroke upper limb motor sequelae rehabilitation: A systematic review
URI https://www.ncbi.nlm.nih.gov/pubmed/37005900
https://www.proquest.com/docview/2800786081
https://search.proquest.com/docview/2794685307
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