Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor

• Published in: Molecular pharmacology Vol. 100; no. 5; pp. 491 - 501
• Main Authors: Brahimi, Fouad, Galan, Alba, Siegel, Sairey, Szobota, Stephanie, Sarunic, Marinko V., Foster, Alan C., Saragovi, H. Uri
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2021
• Subjects: OCT; TNFα; BDNF; pAkt; pTrk; MAPK; MTT; NGF; NT3; ONL; Trk; mAb; RGC; MCF; NGI; FITC; OD; NF; STZ; SFM; pErk; ERK

The neurotrophin growth factors bind and activate two types of cell surface receptors: the tropomyosin receptor kinase (Trk) family and p75. TrkA, TrkB, and TrkC are bound preferentially by nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 (NT3), respectively, to activate ne...