Second Passage of Sheep Scrapie and Transmissible Mink Encephalopathy (TME) Agents in Raccoons (Procyon lotor)

• Published in: Veterinary pathology Vol. 42; no. 6; pp. 844 - 851
• Main Authors: Hamir, A. N, Kunkle, R. A, Miller, J. M, Richt, J. A
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.11.2005
• Subjects: Animals; Blotting, Western - veterinary; disease course; disease transmission; Disease Transmission, Infectious - veterinary; host range; Immunohistochemistry - veterinary; Mink; Models, Animal; prion diseases; Prion Diseases - pathology; Prion Diseases - transmission; Prion Diseases - veterinary; Prions - metabolism; Raccoons; Sheep; Telencephalon - pathology; immunohistochemistry (PrPres), raccoons (Procyon lotor); strain differentiation; sheep scrapie; transmissible mink encephalopathy; spongiform encephalopathy; Cross-species transmission

To determine the transmissibility and pathogenicity of sheep scrapie and transmissible mink encephalopathy (TME) agents derived from raccoons (first passage), raccoon kits were inoculated intracerebrally with either TME (one source) or scrapie (two sources--each in separate groups of raccoons). Two...