Dietary alpha- and gamma-tocopherol (1:5 ratio) supplementation attenuates adipose tissue expansion, hepatic steatosis, and expression of inflammatory markers in a high-fat-diet–fed murine model

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 85; p. 111139
• Main Authors: Juretić, Nevenka, Sepúlveda, Ruth, D'Espessailles, Amanda, Vera, Daniela B., Cadagan, Cynthia, de Miguel, Manuel, González-Mañán, Daniel, Tapia, Gladys
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2021; Elsevier Limited
• Subjects: Adipocytes; Adipose tissue; Animal models; Attenuation; Biomarkers; Body fat; Body weight; Carbohydrates; Cytokines; Diet; Dietary supplements; Drug dosages; Enlargement; Fatty acids; Fatty liver; Gene expression; Hepatic steatosis; High fat diet; IL-1β; Inflammation; Interleukin 1; Laboratory animals; Lipid metabolism; Lipids; Liver; Liver diseases; Metabolism; Microscopy; NF-κB protein; Obesity; Oxidative stress; Peroxisome proliferator-activated receptors; Polymerase chain reaction; Proteins; Steatosis; Tocopherol; Triglycerides; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Vitamin E; United States > US; Obesity; Inflammation; Hepatic steatosis; Lipid metabolism; Tocopherol

The aim of this study was to evaluate the effect of the dietary supplementation of an alpha- and gamma-tocopherol mixture (1:5 ratio) in the adipose tissue expansion, hepatic steatosis, and expression of inflammatory markers induced by consumption of a high-fat diet (HFD) in mice. Male C57BL/6 J mic...