Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing

• Published in: Nucleic acids research Vol. 51; no. 4; pp. 1740 - 1749
• Main Authors: He, Liu, Lever, Rebecca, Cubbon, Andrew, Tehseen, Muhammad, Jenkins, Tabitha, Nottingham, Alice O, Horton, Anya, Betts, Hannah, Fisher, Martin, Hamdan, Samir M, Soultanas, Panos, Bolt, Edward L
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 28.02.2023
• Subjects: DNA - metabolism; DNA Helicases - chemistry; DNA Helicases - metabolism; DNA Polymerase III - genetics; DNA Primers; DNA Replication; Genome Integrity, Repair and; Humans; Proliferating Cell Nuclear Antigen - metabolism

DNA strand breaks are repaired by DNA synthesis from an exposed DNA end paired with a homologous DNA template. DNA polymerase delta (Pol δ) catalyses DNA synthesis in multiple eukaryotic DNA break repair pathways but triggers genome instability unless its activity is restrained. We show that human H...