Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches

• Published in: Clinical science (1979) Vol. 113; no. 1; pp. 1 - 13
• Main Authors: Jansson, Thomas, Powell, Theresa L.
• Format: Journal Article
• Language: English
• Published: London Portland Press 01.07.2007
• Subjects: 11-beta-Hydroxysteroid Dehydrogenases; Biological and medical sciences; Biological Transport; Female; Fetal Development - physiology; General aspects; Humans; Maternal-Fetal Exchange; Medical sciences; Metabolic diseases; Oxidative Stress; Placenta - anatomy & histology; Placenta - blood supply; Placenta - physiology; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena - physiology; Human; Disease; Nutrition; Theory; Chronic disease; Mechanism; Fetal programming; Feeding; Pregnancy; Medicine; Chronic; Fetal development; Placenta; Diet; Etiology; placental transport; maternal-fetal exchange; Female; Fetus; Fetomaternal transfer; Woman; Transport; fetal growth; programming

Adverse influences during fetal life alter the structure and function of distinct cells, organ systems or homoeostatic pathways, thereby ‘programming’ the individual for an increased risk of developing cardiovascular disease and diabetes in adult life. Fetal programming can be caused by a number of...