Base-CP proteasome can serve as a platform for stepwise lid formation

• Published in: Bioscience reports Vol. 35; no. 3
• Main Authors: Yu, Zanlin, Livnat-Levanon, Nurit, Kleifeld, Oded, Mansour, Wissam, Nakasone, Mark A, Castaneda, Carlos A, Dixon, Emma K, Fushman, David, Reis, Noa, Pick, Elah, Glickman, Michael H
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 01.06.2015
• Subjects: Endopeptidases - genetics; Endopeptidases - metabolism; Gene Silencing; Models, Molecular; Mutation; Original Paper; Proteasome Endopeptidase Complex - chemistry; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; Protein Domains; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; 26S proteasome; 19S regulatory particle; lid; PCI; MPN; 20S core particle; base; rpn11-m1

26S proteasome, a major regulatory protease in eukaryotes, consists of a 20S proteolytic core particle (CP) capped by a 19S regulatory particle (RP). The 19S RP is divisible into base and lid sub-complexes. Even within the lid, subunits have been demarcated into two modules: module 1 (Rpn5, Rpn6, Rp...