Deep mutational scanning of SARS-CoV-2 Omicron BA.2.86 and epistatic emergence of the KP.3 variant

• Published in: Virus evolution Vol. 10; no. 1; p. veae067
• Main Authors: Taylor, Ashley L, Starr, Tyler N
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 2024
• Subjects: Mutation; Severe acute respiratory syndrome coronavirus 2; SARS-CoV-2; Omicron; epistasis; deep mutational scanning

Abstract Deep mutational scanning experiments aid in the surveillance and forecasting of viral evolution by providing prospective measurements of mutational effects on viral traits, but epistatic shifts in the impacts of mutations can hinder viral forecasting when measurements were made in outdated...