The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19
It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pat...
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Published in | Turkish journal of medical sciences Vol. 50; no. 8; pp. 1786 - 1791 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Turkey
The Scientific and Technological Research Council of Turkey
17.12.2020
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Abstract | It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway and leukotrienes (LT) in uncontrolled immune response that occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
This study included 25 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum TWEAK, LTE4, and prostaglandin F2α (PGF2α) levels were determined.
Compared with the healthy control group, TWEAK, LTE4, and PGF2α levels were higher in the group of SARS-CoV-2 infection without lung involvement. In the group of SARS-CoV-2 infection with lung involvement, age, fibrinogen, sedimentation, C-reactive protein and ferritin, TWEAK, LTE4, and PGF2α levels were higher, and lymphocyte levels were lower compared with the asymptomatic group.
In the study, TWEAK and LTE4 levels increased in cases with COVID-19. These results support that TWEAK/Fn14 pathway and LT may involved in the pathology of aberrant immune response against SARS-CoV-2. Inhibition of each of these pathways may be a potential target in the treatment of COVID-19. |
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AbstractList | It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway and leukotrienes (LT) in uncontrolled immune response that occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
This study included 25 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum TWEAK, LTE4, and prostaglandin F2α (PGF2α) levels were determined.
Compared with the healthy control group, TWEAK, LTE4, and PGF2α levels were higher in the group of SARS-CoV-2 infection without lung involvement. In the group of SARS-CoV-2 infection with lung involvement, age, fibrinogen, sedimentation, C-reactive protein and ferritin, TWEAK, LTE4, and PGF2α levels were higher, and lymphocyte levels were lower compared with the asymptomatic group.
In the study, TWEAK and LTE4 levels increased in cases with COVID-19. These results support that TWEAK/Fn14 pathway and LT may involved in the pathology of aberrant immune response against SARS-CoV-2. Inhibition of each of these pathways may be a potential target in the treatment of COVID-19. |
Author | Günaydin, Caner Cihangiroğlu, Mustafa Çapraz, Mustafa Özgen, Metin Sehmen, Emine Avcı, Bahattin Boran, Maruf Yalçın Kehribar, Demet |
Author_xml | – sequence: 1 givenname: Demet orcidid: 0000-0002-1852-7981 surname: Yalçın Kehribar fullname: Yalçın Kehribar, Demet organization: Department of Internal Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey – sequence: 2 givenname: Mustafa orcidid: 0000-0001-6148-5142 surname: Cihangiroğlu fullname: Cihangiroğlu, Mustafa organization: Department of Infection Diseases and Clinical Microbiology, Faculty of Medicine, Amasya University, Amasya, Turkey – sequence: 3 givenname: Emine orcidid: 0000-0002-4267-9889 surname: Sehmen fullname: Sehmen, Emine organization: Department of Infection Diseases, Gazi State Hospital, Samsun, Turkey – sequence: 4 givenname: Bahattin orcidid: 0000-0001-6471-6495 surname: Avcı fullname: Avcı, Bahattin organization: Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey – sequence: 5 givenname: Mustafa orcidid: 0000-0001-9586-6509 surname: Çapraz fullname: Çapraz, Mustafa organization: Department of Internal Medicine, Faculty of Medicine, Amasya University, Amasya, Turkey – sequence: 6 givenname: Maruf orcidid: 0000-0002-2494-9152 surname: Boran fullname: Boran, Maruf organization: Department of Intensive Care Unit, Faculty of Medicine, Amasya University, Amasya, Turkey – sequence: 7 givenname: Caner orcidid: 0000-0002-9811-3139 surname: Günaydin fullname: Günaydin, Caner organization: Department of Pharmacology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey – sequence: 8 givenname: Metin orcidid: 0000-0002-6842-2918 surname: Özgen fullname: Özgen, Metin organization: Department of Rheumatology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey |
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Keywords | COVID - 19 TWEAK inflammation prostaglandin leukotrienes |
Language | English |
License | This work is licensed under a Creative Commons Attribution 4.0 International License. This article is distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
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SubjectTerms | Correlation of Data COVID-19 - diagnosis COVID-19 - immunology Cytokine TWEAK - blood Dinoprost - blood Female Humans Leukotriene E4 - blood Lung - diagnostic imaging Male Middle Aged Signal Transduction - immunology TWEAK Receptor - metabolism |
Title | The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19 |
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