Performance of free β-human chorionic gonadotrophin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) analysis between Delfia Xpress and AutoDelfia systems in The Netherlands

• Published in: Clinical chemistry and laboratory medicine Vol. 47; no. 2; pp. 222 - 226
• Main Authors: Linskens, Ingeborg H., Levitus, Marieke, Frans, Anneke, Schielen, Peter C.J.I., van Vugt, John M.G., Blankenstein, Marinus A., Dijstelbloem, Hilde M.
• Format: Journal Article
• Language: English
• Published: Germany Walter de Gruyter 01.02.2009
• Subjects: AutoDelfia; Chorionic Gonadotropin, beta Subunit, Human - blood; Delfia Xpress; Down Syndrome - blood; Down Syndrome - diagnosis; first trimester Down syndrome screening; free β-human chorionic gonadotrophin; Humans; Immunoassay - instrumentation; Immunoassay - methods; Netherlands; Predictive Value of Tests; pregnancy associated plasma protein-A; Pregnancy-Associated Plasma Protein-A - analysis; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Netherlands

Background: The VU University Medical Center (VUmc) was the first hospital in the Netherlands to introduce the Delfia Xpress for the analysis of free β-human chorionic gonadotrophin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester screening program for Down syndrome....