Insulin-Sensitizing Effects on Muscle and Adipose Tissue after Dietary Fiber Intake in Men and Women with Metabolic Syndrome

• Published in: The journal of clinical endocrinology and metabolism Vol. 97; no. 9; pp. 3326 - 3332
• Main Authors: Robertson, M. Denise, Wright, John W., Loizon, Emmanuelle, Debard, Cyrille, Vidal, Hubert, Shojaee-Moradie, Fariba, Russell-Jones, David, Umpleby, A. Margot
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.09.2012; Endocrine Society
• Subjects: Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Adult; Aged; Biological and medical sciences; Biomarkers - analysis; Biomarkers - metabolism; Biopsy; Body fat; Cytokines - metabolism; Diabetes; Diabetes mellitus (non-insulin dependent); Diet; Dietary fiber; Dietary Fiber - pharmacology; Dietary intake; Endocrinology; Endocrinopathies; Epidemiology; Feeding. Feeding behavior; Female; Forearm; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression - drug effects; Glucose; Glucose - metabolism; Glucose Clamp Technique; Glucose tolerance; Humans; Insulin resistance; Insulin Resistance - physiology; Lipase; Lipid Metabolism - drug effects; Lipids; Lipoprotein lipase; Liver; Liver - metabolism; Male; Medical sciences; Membrane Potentials - drug effects; Metabolic syndrome; Metabolic Syndrome - diet therapy; Metabolic Syndrome - metabolism; Metabolic Syndrome - physiopathology; Middle Aged; Muscles - drug effects; Muscles - metabolism; Real-Time Polymerase Chain Reaction; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Sampling; Single-Blind Method; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Zea mays - chemistry; Endocrinopathy; Human; Obesity; Pancreatic hormone; Adipose tissue; Nutrition; Nutrition disorder; Sex; Cardiovascular disease; Metabolic diseases; Male; Metabolic syndrome; Insulin; Female; Muscle; Woman; Dietary fiber; Endocrinology; Nutritional status

Context:Dietary fibers have been associated with a reduced incidence of type 2 diabetes mellitus in epidemiological studies; however, the precise mechanisms are unknown.Objective:The objective of the study was to evaluate the efficacy and site of action of an insoluble dietary fiber derived from mai...