Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture

• Published in: Osteoporosis international Vol. 17; no. 6; pp. 807 - 816
• Main Authors: Vestergaard, P., Rejnmark, L., Mosekilde, L.
• Format: Journal Article
• Language: English
• Published: London Springer 01.06.2006; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Anti-Anxiety Agents - adverse effects; Antidepressants; Antidepressive Agents - adverse effects; Antipsychotic Agents - adverse effects; Antipsychotics; Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Denmark - epidemiology; Disease; Diseases of the osteoarticular system; Dose-Response Relationship, Drug; Drug dosages; Female; Fractures; Fractures, Bone - chemically induced; Fractures, Bone - epidemiology; Hospital Records; Hospitals; Humans; Hypnotics and Sedatives - adverse effects; Infant; Injuries of the limb. Injuries of the spine; Male; Medical sciences; Mental depression; Middle Aged; Odds Ratio; Osteoporosis; Osteoporosis. Osteomalacia. Paget disease; Prescription drugs; Reimbursement; Risk Factors; Scandals; Tranquilizers; Traumas. Diseases due to physical agents; Denmark; Aarhus Denmark; Sedatives; Osteoporosis; Neuroleptics; Antidepressants; Diseases of the osteoarticular system; Risk factor; Rheumatology; Fracture; Sedative; Trauma; Anxiolytics

Our objective was to study the association between fracture risk and the use of anxiolytics and sedatives (benzodiazepines, etc.), neuroleptics and antidepressants. This was a case control study. All cases consisted of subjects who had sustained a fracture during the year 2000 (n=124,655). For each...