Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli

• Published in: The American journal of clinical nutrition Vol. 82; no. 6; pp. 1283 - 1291
• Main Authors: Gasper, Amy V, Al-janobi, Ahmed, Smith, Julie A, Bacon, James R, Fortun, Paul, Atherton, Clare, Taylor, Moira A, Hawkey, Christopher J, Barrett, David A, Mithen, Richard F
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Clinical Nutrition 01.12.2005; American Society for Clinical Nutrition, Inc
• Subjects: Adolescent; Adult; Alleles; anticarcinogenic activity; antinutritional factors; Area Under Curve; biochemical pathways; Biological and medical sciences; Brassica - chemistry; Brassica oleracea var. italica; broccoli; chemical composition; chemoprevention; Comparative analysis; Cross-Over Studies; Double-Blind Method; Female; Food industries; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; Genetics; Genotype & phenotype; glucobrassicin; Glucosinolates - administration & dosage; Glucosinolates - metabolism; glutathione transferase; Glutathione Transferase - deficiency; Glutathione Transferase - genetics; Humans; Isothiocyanates; Male; metabolic detoxification; Metabolism; Middle Aged; Neoplasms - prevention & control; nutrition-genotype interaction; Polymorphism; Polymorphism, Genetic; randomized clinical trials; Risk Factors; structure-activity relationships; Sulfoxides; Thiocyanates - blood; Thiocyanates - pharmacokinetics; Thiocyanates - urine; Vegetables; Human; Glucosinolate; Vegetables; GSTM1; Enzyme; Transferases; Metabolism; Feeding; super broccoli; Broccoli; Food intake; Glutathione transferase; Sulforaphane; glucosinolates; Isothiocyanates; chemoprotection; Polymorphism

Broccoli consumption is associated with a reduction in the risk of cancer, particularly in persons with a functional glutathione S-transferase M1 allele, as opposed rotrose whose GSTM1 gene has been deleted. Sulforaphane, the major isothiocyanate derived from 4-methylsulfinylbutyl glucosinolate, is...