Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli - Gasper, Amy V; Al-janobi, Ahmed; Smith, Julie A; Bacon, James R; Fortun, Paul; Atherton, Clare; Taylor, Moira A; Hawkey, Christopher J; Barrett, David A; Mithen, Richard F (The American journal of clinical nutrition, 2005)
Keywords: Adolescent; Adult; Alleles; anticarcinogenic activity; antinutritional factors; Area Under Curve; biochemical pathways; Biological and medical sciences; Brassica - chemistry; Brassica oleracea var. italica; broccoli; chemical composition; chemoprevention; Comparative analysis; Cross-Over Studies; Double-Blind Method; Female; Food industries; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; Genetics; Genotype & phenotype; glucobrassicin; Glucosinolates - administration & dosage; Glucosinolates - metabolism; glutathione transferase; Glutathione Transferase - deficiency; Glutathione Transferase - genetics; Humans; Isothiocyanates; Male; metabolic detoxification; Metabolism; Middle Aged; Neoplasms - prevention & control; nutrition-genotype interaction; Polymorphism; Polymorphism, Genetic; randomized clinical trials; Risk Factors; structure-activity relationships; Sulfoxides; Thiocyanates - blood; Thiocyanates - pharmacokinetics; Thiocyanates - urine; Vegetables; Human; Glucosinolate; Vegetables; GSTM1; Enzyme; Transferases; Metabolism; Feeding; super broccoli; Broccoli; Food intake; Glutathione transferase; Sulforaphane; glucosinolates; Isothiocyanates; chemoprotection; Polymorphism