Antihypertensive effect of betaxolol, a cardioselective beta-adrenoceptor antagonist, in experimental hypertensive rats

• Published in: Nihon yakurigaku zasshi Vol. 95; no. 6; p. 347
• Main Authors: Bessho, H, Suzuki, J, Narimatsu, A, Tobe, A
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.06.1990
• Subjects: Administration, Oral; Adrenergic beta-Antagonists - administration & dosage; Adrenergic beta-Antagonists - therapeutic use; Animals; Betaxolol - administration & dosage; Betaxolol - therapeutic use; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension - drug therapy; Hypertension - physiopathology; Male; Rats; Rats, Inbred SHR; Vascular Resistance

Betaxolol is a highly selective beta 1-adrenoceptor antagonist without intrinsic sympathomimetic activity. In this study, the antihypertensive effect of betaxolol was investigated in experimental hypertensive rats; and the antihypertensive mechanism was also studied. Betaxolol (1 and 10 mg/kg, p.o.)...